DNA Excision Repair Protein ERCC-4
[DNA Excision Repair Protein ERCC-4, encoded by the ERCC4 gene, is a DNA repair protein. Nucleotide excision repair (NER) involves incision of a DNA strand on each side of a lesion. The two incisions made during NER are catalyzed by separate DNA endonucleases. A tight protein complex formed between ERCC4 and ERCC1 acts as a structure-specific endonuclease for the 5-prime incision during repair. Without DNA damage, this complex moves freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC4/ERCC1 due to engagement of the complex in a single repair event after assembly of individual nucleotide excision repair factors at sites of DNA damage in a distributive fashion. Causative mutations in the ERCC4 gene and strongly reduced levels of encoded protein can be identified in patients with xeroderma pigmentosum type F. (From OMIM and NCI) ( NCI )]
UMLS (NCI) C1333231ERCC4
RAD1
XPF
RAD1
XPF
- Amino Acid, Peptide, or Protein
- Enzyme
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