Dirithromycin
[A semi-synthetic macrolide antibiotic pro-drug. Dirithromycin is converted by hydrolysis during intestinal absorption into the microbiologically active erythromycylamine. Eryhtromylamine binds to the 50 S subunit of the 70 S ribosome of susceptible organisms, thereby inhibiting bacterial RNA-dependent protein synthesis. This antibiotic is used in the treatment of infections of the respiratory tract, skin and soft tissue caused by gram-postive microorganisms, including S. aureus, S. pneumonia and pyogenes, gram-negative microorganisms, including H. influenzae, L. pneumophila, M. catarrhalis, and M. pneumoniae. ( NCI )]
UMLS (NCI) C0058445- Organic Chemical
- Antibiotic
Relation/PAR: ERYTHROMYCIN
[AM200] ERYTHROMYCINS/MACROLIDES
[AM200] ERYTHROMYCINS/MACROLIDES
Relation/CHD: DIRITHROMYCIN 250 MG
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