EIF2AK1
[Expressed by interferon-induced human PRKR Gene (GCN2 Family), 551-aa 62-kDa Interferon-Inducible elF2Alpha Kinase is a homodimeric serine/threonine protein kinase containing 2 DRBM domains that is activated by double-stranded RNA in the presence of ATP. Binding to dsRNA induces PRKR dimerization and activation, leading to autophosphorylation in the activation loop, PRKR phosphorylation of EIF2-alpha, and inhibition of protein synthesis initiation. P58(IPK) inhibition by P52(rIPK) upregulates PRKR activity. IFNG mRNA activates PRKR through a conserved 5-prime UTR pseudoknot to control its own translation yield. HCV envelope protein E2 contains a sequence identical to phosphorylation sites of PRKR and EIF2-alpha. E2 inhibits PRKR inhibitory activity on protein synthesis and cell growth, which may contribute to HCV-associated hepatocellular carcinoma. (NCI) ( NCI )]
UMLS (NCI) C0058980- Amino Acid, Peptide, or Protein
- Enzyme
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
