[Widely expressed at growth arrest by human GAS2 Gene, 36-kD Growth-Arrest-Specific Protein 2 is a component of the microfilament system. Localized at the actin cytoskeleton, along stress fibers, and at the plasma membrane, GS2 is phosphorylated on serine residues during G0/G1 transition. Hyperphosphorylated GAS2 accumulates at membrane ruffles. In apoptosis, GAS2 is a substrate for caspases; cleaved forms of GAS2 induce actin cytoskeletal rearrangements and cell shape changes. (NCI) ( NCI )]
UMLS (NCI) C0389006 - Amino Acid, Peptide, or Protein
- Biologically Active Substance