GDNF Family Receptor Alpha 2

[GDNF Family Receptor Alpha 2, encoded by the human GFRA2 gene, is a member of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Receptor family. GDNF and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 is required for the development of the myenteric nerve plexus. This protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This receptor acts preferentially as a receptor for NTN compared to its other family member, GDNF Family Receptor Alpha 1. Two alternatively spliced transcript variants, long and short, have been described for this gene but their full length nature is not known. The short form is found in brain and placenta. This gene is a candidate gene for RET-associated diseases. (From LocusLink, OMIM, Swiss-Prot and NCI) ( NCI )]

UMLS (NCI) C1457885

GDNF Family Receptor Alpha-2
GDNF Receptor Beta
GDNFRB
GDNFR-Beta
GFRA2
GFRA2 Protein
GFR-Alpha 2
Glial Cell Line Derived Neurotrophic Factor Receptor, Beta
Glial Cell Line-Derived Neurotrophic Factor Receptor Beta
Neurturin Receptor Alpha
NRTNR-ALPHA
NTNRA
NTNR-Alpha
PI-Linked Cell-Surface Accessory Protein
RET Ligand 2
RETL2
TGF-Beta Related Neurotrophic Factor Receptor 2
TRN Receptor, GPI-Anchored
TRNR2

Amino Acid, Peptide, or Protein
Receptor

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