[An epipodophyllotoxin analogue possessing antineoplastic properties. GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. (NCI) ( NCI )]
UMLS (NCI) C0908996 - Organic Chemical
- Pharmacologic Substance