GLIMEPIRIDE
[A sulfonylurea with antihyperglycemic activity. Glimepiride binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, thereby reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-gated calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin, and thereby results in a reduction of the blood glucose level. In addition, this agent increases the sensitivity of peripheral tissues to insulin. ( NCI )]
UMLS (NCI) C0061323- Organic Chemical
- Pharmacologic Substance
Relation/PAR: sulfonylurea
[HS502] HYPOGLYCEMIC AGENTS, ORAL
[HS502] HYPOGLYCEMIC AGENTS, ORAL
Relation/CHD: GLIMEPIRIDE 1 MG
GLIMEPIRIDE 4 MG
GLIMEPIRIDE 2 MG
GLIMEPIRIDE 4 MG
GLIMEPIRIDE 2 MG
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