[Widely expressed and encoded by human LGALS3BP Gene (MSR1 Superfamily), 585-amino acid extracellular Galectin 3 Binding Protein contains an N-terminal MSR1 Cys-rich domain and binds LGALS3 via carbohydrate-specific interaction. MAC2BP is a potent stimulator of host immune defense systems, such as NK and LAK cell cytotoxicity, and can induce IL2 cytokine production. Oncogenic transformation, viral infection, or pathogen invasion enhance MAC2BP production. LGALS3BP is elevated in the serum of cancer and HIV patients. (from LocusLink, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0217525 - Amino Acid, Peptide, or Protein
- Immunologic Factor
- Indicator, Reagent, or Diagnostic Aid