Glucocorticoid Receptor-Interacting Protein-1
[Involved in cell growth, development, and homeostasis, 292-kb human NCOA2 Gene at 8q13.2 encodes 1464-aa 159-kD transcriptional coactivator TIF2, containing N-terminal bHLH and PAS dimerization domains. Present in a complex with NCOA3, IKKA/B, IKBKG, and CREBBP histone acetyltransferase, TIF2 interacts with HIF1A, APEX, NR3C1, and perhaps NR3C2. TIF2 coactivator interacts with steroid receptor superfamily hormone binding domains in a hormone-dependent manner. Recruitment of CBP/p300 and PCAF coactivators for myogenic MYOD and MEF2 expression depends on NCOA1, NCOA2, and NCOA3. NCOA2 is also required for expression of MYOG and CDKN1A, and for myogenic differentiation. The NCOA2 bHLH/PAS and C-terminal activation domains mediate coactivation of MEF2C through its MADS box. The NCOA2 N- and C-termini interact with MYOG. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1411929NCOA2
NCoA-2
Nuclear Receptor Coactivator 2
Nuclear Receptor Coactivator-2
TIF2
TIF2/GRIP-1
Transcriptional Intermediary Factor 2
NCoA-2
Nuclear Receptor Coactivator 2
Nuclear Receptor Coactivator-2
TIF2
TIF2/GRIP-1
Transcriptional Intermediary Factor 2
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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