Glucocorticoid Receptor
[Widely expressed by human NR3C1 Gene (NR3 Family) as 6 isoforms, phosphorylated cytoplasmic (inactive)/hyperphosphorylated nuclear (active) Glucocorticoid Receptor contains a (N) modulating domain, a DNA-binding domain, and a (C) steroid-binding domain. Alpha-A (777-aa, 86-kDa precursor) predominates. Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activate GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation. GR defects cause glucocorticoid resistance. (NCI) ( NCI )]
UMLS (NCI) C1370369Glucocorticoid Receptor, Lymphocyte
NR3C1
Nuclear Receptor Subfamily 3, Group C, Member 1
NR3C1
Nuclear Receptor Subfamily 3, Group C, Member 1
- Amino Acid, Peptide, or Protein
- Receptor
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