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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
G G0 G1 G2 G3 G4 GA GB GC GD GE GF GG GH GI GL GM GN GO GP GQ GR GS GT GU GV GW GX GY GZ G%
GL GL3 GL7 GLA GLE GLI GLL GLM GLN GLO GLP GLU GLV GLY

Glutaminase-Asparaginase

[A dual function enzyme derived from bacterial Acinetobacter glutaminasificans used as an adjuvant in chemotherapy. Acinetobacter glutaminase-asparaginase (AGA) possesses both L-glutaminase and L-asparaginase activities, capable of hydrolyzing glutamine and asparagine, thereby disturbing nitrogen supplies for dividing cells. When co-administered with alkylating agent melphalan, which utilizing amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity. ( NCI )]
UMLS (NCI) C0071561
 
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Enzyme

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