HDAC5

1. [This gene plays a role in chromatin remodeling, repression of gene expression and control of cellular differentiation. ( NCI )]
   UMLS (NCI) C1333894
   
   HDAC5 Gene
   Histone Deacetylase 5 Gene
    

   Gene or Genome
   

2. [This protein belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. The gene is thought to be associated with colon cancer. Overexpression inhibits cell growth and induces apoptosis in tumor cell lines. (from LocusLink and Cancer Res 2002;62:2913-22) ( NCI )]
   UMLS (NCI) C1334033
   
   Histone Deacetylase 5
    

   Amino Acid, Peptide, or Protein

   Enzyme