[HMGA1b, encoded by the HMGA1 gene, preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It is involved in transcriptional regulation of the BRCA1 gene. HMGA1b overexpression accounts for BRCA1 downregulation in sporadic breast carcinomas. (From PubMed 12640109 and NCI) ( NCI )]
UMLS (NCI) C0379832 - Amino Acid, Peptide, or Protein
- Biologically Active Substance