Human Homolog 4 of Drosophila Notch4 Protein
[NOTCH4 Protein is a Drosophila Notch receptor homologue with 29 extracellular EGF-like repeats, three Notch/lin-12 repeats, a transmembrane region, six intracellular cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region. A component of an evolutionarily conserved intercellular signaling mechanism, NOTCH4 is expressed in a variety of tissues and appears to regulate cell fate decisions during embryonic vascular morphogenesis and remodeling. NOTCH4 and NOTCH1 appear to have partially overlapping roles during embryogenesis in mice. MMTV INT3 interruption of NOTCH4 produces a gain-of-function truncated product, containing only the transmembrane and intracellular domains, that has profound consequences for mammary gland development and tumorigenesis. (from OMIM 164951 and NCI) ( NCI )]
UMLS (NCI) C0539211- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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