IGF Binding Protein 4

[IGFBP4 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP4 contains a thyroglobulin type-I domain and binds IGF-II more than IGF-I. IGFBP4 inhibits IGF-induced bone cell proliferation. (from OMIM 146733, SWISS-PROT P22692, and NCI) ( NCI )]

UMLS (NCI) C0123258

Amino Acid, Peptide, or Protein
Biologically Active Substance

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