IGFBP6

1. [This gene plays an inhibitory role in the regulation of cellular growth. ( NCI )]
   UMLS (NCI) C1367148
   
   IGFBP6 Gene
   Insulin-Like Growth Factor Binding Protein 6 Gene
    

   Gene or Genome

2. [IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI) ( NCI )]
   UMLS (NCI) C1442822
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance