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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
L L L- L0 L1 L6 LA LB LC LD LE LF LG LH LI LK LL LM LN LO LP LR LS LT LU LV LX LY
LI LIA LIB LIC LID LIE LIF LIG LII LIK LIL LIM LIN LIO LIP LIQ LIR LIS LIT LIV LIZ

Licorice Root Extract

[An herbal extract derived from the root of the plant Glycyrrhiza glabra with potential anti-inflammatory, antioxidant and antineoplastic activities. Licorice root extract contains glycoside glycyrrhizinic acid and numerous flavonoids. Glycyrrhizinic acid is hydrolyzed to glycyrrhetic acid that inhibits 11 beta-hydroxysteroid dehydrogenase, resulting in inhibition of the conversion of cortisol to the inactive steroid cortisone and elevated cortisol levels. In addition, GA inhibits 17,20-lyase and 17 beta-hydroxysteroid dehydrogenase, resulting in decreased conversions of 17-hydroxyprogesterone to androstenedione and androstenedione to testosterone. The primary antioxidant found in licorice root, the flavonoid glabridin, may inactivate or inhibit the activities of some human P450 enzymes. In tumor cells, beta-hydroxy-DHP, another flavonoid, may induce Bcl-2 phosphorylation, apoptosis, and G2/M cell cycle arrest. ( NCI )]
UMLS (NCI) C0770612
 
Organic Chemical
Pharmacologic Substance

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