MUC-2-Globo H-KLH Conjugate Vaccine
[A bivalent vaccine containing a glycosylated epitope of human mucin 2 (MUC2) and the Globo H hexasaccharide 1 (Globo H) antigen with potential antineoplastic activity. MUC2, a secretory or gel forming glycoprotein expressed predominantly in goblet cells of gastrointestinal and respiratory tracts, is overexpressed as an aberrant or deglycosylated form in various tumors such as gastric carcinomas and some hormone-refractory prostate cancers. Originally identified as a globo-series glycosphingolipid with an H-like determinant, Globo H is an epitope commonly found in glycolipids and glycoproteins, including mucins. This vaccine is conjugated with keyhole limpet hemocyanin (KLH), an immunostimulant and a hapten carrier, to enhance immune recognition and stability of the vaccine. Vaccination with this agent may elicit strong antibodies production as well as a cytotoxic T lymphocyte (CTL) response against tumor cells expressing MUC2 or Globo H. ( NCI )]
UMLS (NCI) C0935832- Organic Chemical
- Pharmacologic Substance
- Immunologic Factor
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
