[The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time. ( NCI )]
UMLS (NCI) C0795668Tirofiban Hydrochloride
TIROFIBAN HYDROCHLORIDE PREPARATION
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: tirofiban
Relation/CHD: TIROFIBAN HYDROCHLORIDE 250 MCG/ML
TIROFIBAN HYDROCHLORIDE 50 MCG/ML