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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
N N- N0 N3 NA NB NC ND NE NF NG NH NI NK NL NM NN NO NP NR NS NT NU NV NX NY NZ
NC NC- NCA NCC NCH NCI NCK NCN NCO NCS NCX NCY

N-[1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl]-2-oxo-1,2-dihydropyrimidin-4-yl}hexadecanamide

[An orally bioavailable pyrimidine analog with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analog CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into its active triphosphate form. As an analog of deoxycytidine triphosphate, CNDAC triphosphate molecules get incorporated into DNA strands during replication, thereby leading to single-stranded DNA breaks caused by beta-elimination in fidelity check point. As a result, this agent induces cell cycle arrest in the G2 phase and subsequently triggers apoptosis. ( NCI )]
UMLS (NCI) C0764827
Sapacitabine
 
Organic Chemical

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