NR0B2

1. [This gene is involved in transcriptional regulation and can stimulate transcriptional repression. ( NCI )]
   UMLS (NCI) C1334896
   
   NR0B2 Gene
   Nuclear Receptor Subfamily 0, Group B, Member 2 Gene
    

   Gene or Genome
   

2. [Expressed in small intestine, spleen, liver, heart, adrenal gland, and pancreas, human NR0B2 Gene (NR0 Family) encodes 257-aa 28-kDa Orphan Nuclear Receptor SHP, containing a putative ligand-binding domain and a dimerization domain, but lacking a conventional DNA-binding domain. SHP heterodimerizes with nuclear hormone receptors ESR, RAR, RXR, TR, and NR1I3, specifically inhibiting their ligand-dependent transcriptional activation pathways. SHP may repress nuclear receptor-mediated transactivation via two steps: competition with coactivators and direct transcriptional repression. (NCI) ( NCI )]
   UMLS (NCI) C1335142
   
   Nuclear Receptor Subfamily 0 Group B Member 2
   Orphan Nuclear Receptor SHP
   Short Heterodimer Partner
   SHP
   SHP1
   
    

   Amino Acid, Peptide, or Protein

   Receptor