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PA-1-STK Ovarian Carcinoma Vaccine
[A cell-based gene transfer with potential antineoplastic activity. PA-1 STK ovarian carcinoma vaccine is produced by transducing the ovarian cancer cell line, PA-1, with a retrovirus (STK) encoding the herpes simplex thymidine kinase (HSV-tk) gene, resulting in a cell line that permanently expresses the HSV tk gene. Upon transfection into malignant cells, this vaccine is capable of sensitizing tumor cells in response to an antiviral drug such as ganciclovir, which is readily phosphorylated by the TK enzyme to its active form. Administration of ganciclovir following PA-1 STK transfection results in enhanced cytotoxicity of the transfected tumor cells. Additionally, adjacent non-transfected cells are killed by the activated antiviral drug, a phenomena referred to as the bystander effect and which is commonly described with this type of suicide-gene transfer. ( NCI )]
UMLS (NCI) C0393067- Pharmacologic Substance
- Immunologic Factor
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