[Encoded by human PPP2R1B Gene (PP2A Subunit A Family), 601-aa 66-kDa Protein Phosphatase 2 Regulatory Subunit A Beta contains 15 HEAT repeats that form a rod-like structure consisting of alpha helices joined by a hydrophilic loop. PPP2R1B is a constant regulatory/scaffolding subunit of PP2 that coordinates assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase in cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. PPP2R1B interacts with IPO9. (NCI) ( NCI )]
UMLS (NCI) C1448071PP2A Subunit A R1-Beta
PPP2R1B
Protein Phosphatase 2 Regulatory Subunit A Beta
Protein Phosphatase 2 Structural/Regulatory Subunit A Beta
Serine/Threonine Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta
- Amino Acid, Peptide, or Protein
- Biologically Active Substance