RARA
[A protein that binds retinoic acid with high affinity, RAR alpha is homologous to the steroid receptor superfamily and a retinoic acid-inducible transacting enhancer factor. There are at least two retinoic acid receptors, RAR alpha and RAR beta. Binding of ligand to receptors attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. The repressor function of SMRT may promote interaction with transcription factor TFIIB. (from OMIM 180240 and NCI) ( NCI )]
UMLS (NCI) C0140279- Amino Acid, Peptide, or Protein
- Receptor
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