[A chimeric SIL/SCL locus, produced by interstitial deletion between SIL and the 5-prime untranslated region of SCL and disrupting the SCL regulatory region, has been observed. SCL mRNA expression becomes regulated by the SIL promoter, leading to inappropriate SCL expression. This type of rearrangement is frequently seen in T-cell acute lymphoblastic leukemia. (from OMIM 181590 and NCI) ( NCI )]
UMLS (NCI) C1335825 - Amino Acid, Peptide, or Protein
- Biologically Active Substance