SKIL

1. [This gene plays a role in signal transduction. It is involved in regulating whether cells undergo differentiation or division. ( NCI )]
   UMLS (NCI) C1335828
   
   SKIL Gene
   SKI-Like Gene
   
    

   Gene or Genome
   

2. [SKI-Like Protein SKIL is widely expressed by human SKIL Gene with immediate early kinetics upon serum stimulation as alternative isoforms: SNON (684-aa), SNOA (415-aa), SNON2, SNOI (skeletal muscle restricted). A component of the TGFB/SMAD pathway, SNON interacts with SMAD2/3 and regulates cell growth and cell differentiation signaling. Absent TGFB, SNON binds nuclear SMAD4 and represses target gene promoter activity. APC activator CDH1 forms a complex with SNON, SMAD3, and TGFB-regulated ubiquitin ligase APC, regulating SNON degradation. TGFB activates SMAD2/3/4 nuclear translocation. SNON degradation allows SMAD2/4 to activate TGFB target genes. TGFB also induces SNON expression, which binds to SMAD complexes and shuts off TGFB signaling. (NCI) ( NCI )]
   UMLS (NCI) C1448598
   
   SKI-Like
   SKI-Like Protein SKIL
   SKI-Related Oncogene SNON Protein
   SKI-Related Protein
   SNO
   SNOA
   SNON
   
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance