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SL11047
[A second generation polyamine analog synthesized through the restriction of molecular conformations of parent polyamine compounds with potential antineoplastic activity. SL-11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth. ( NCI )]
UMLS (NCI) C0962042SL-11047
- Organic Chemical
- Pharmacologic Substance
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