S S S- S0 S1 S2 S3 S4 S5 S6 S7 S8 S9 SA SB SC SD SE SF SG SH SI SJ SK SL SM SN SO SP SQ SR SS ST SU SV SW SY
Signal Transducer and Activator of Transcription 5A
[This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart is found to induce the expression of BCL2L1/BCL-X(L), which suggests an antiapoptotic function in cells. (from LocusLink) ( NCI )]
UMLS (NCI) C1366394STAT1
STAT5A
STAT5A
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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