[An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation. ( NCI )]
UMLS (NCI) C0040341 Relation/PAR: [AM300] AMINOGLYCOSIDES
Nebramycin
[OP201] ANTIBACTERIALS, TOPICAL OPHTHALMIC
[RE900] RESPIRATORY AGENTS, OTHER
Relation/CHD: TOBRAMYCIN SULFATE
TOBRAMYCIN 300 MG/5ML
TOBRAMYCIN 0.3 %