Wingless-Type MMTV Integration Site Family Member 4 Protein
[Encoded by human WNT4 Gene, 351-amino acid 39 kD (precursor) WNT4 Protein (WNT Family) is a putative secreted paracrine cysteine-rich glycoprotein ligand for a seven transmembrane frizzled receptor influencing sex-determination. WNT family signaling proteins regulate cell fate and patterning during embryogenesis. WNT4 is similar to mouse and rat proteins Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, and Wnt7b, which contain 83 conserved amino acid residues, including 21 cysteines. Wnt4 is detected in brain, lung, and kidney mesenchyme. Wnt4 appears to be an autoinducer of nephric mesenchyme-to-epithelial transition. WNT4 up regulates DAX1 (antagonizes SRY) controlling female development and preventing testes formation. WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue. (from SWISS-PROT, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1337003WNT4
WNT4 Protein
WNT4 Protein
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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