- 2. Abundant SRC Homology
- [GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced activation of RAS. It also acts to link PDGFRB to the Rac signaling pathway. Due to its ability to cause complex formation between proteins involved in growth signaling pathways, GRB2 has been referred to as an adaptor protein. (from LocusLink and OMIM) ( NCI )] (UMLS (NCI) C0170953) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 6. Abused Substances
- [Any substance, including any illegal, prescription, over-the-counter agent or any other compound, used for the purpose other than indicated or used in quantities other than directed. Substances from various drug classes can be abused, such as opioids, amphetamines, analgesics, benzodiazepines, barbiturates, hallucinogens, steroids, tobacco products and alcoholic substances. A substance of abuse may act on the central nervous system (CNS) or can have an effect in other parts of the body and can lead to physical and/or physiological dependence. ( NCI )] (UMLS (NCI) C0687130) =Hazardous or Poisonous Substance
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