[Encoded by human MLLT6 Gene, 1093-aa 112-kDa AF-17 Protein has high similarity to AF10 and contains amino acid stretches associated with transcriptional repression or activation: a 3-prime leucine-zipper dimerization motif and a terminal cysteine-rich domain of 3 zinc fingers (2 PHD-type) similar to a domain in Br140 protein. A common acute leukemia chromosomal translocation t(11;17)(q23;q21) involves fusion of MLL/HRX and MLLT6 that produces a rogue activator protein. ( NCI )] (UMLS (NCI) C1307583) AF-17 Protein; MLLT6; Trithorax Homolog 6; =Amino Acid, Peptide, or Protein; Biologically Active Substance