- 1. APO
- (UMLS (NCI) C0285452) =Therapeutic or Preventive Procedure ;
| - 24. Aponeurosis
- (UMLS (NCI) C0225205) =Tissue
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- 2. Apo B
- [structural proteins of chylomicrons, VLDL, and LDL; important in secretion and transport of lipoproteins; binding proteins for LDL receptor pathway. ( CSP )] (UMLS (CSP) C0003593) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 25. Apopain
- [Caspase-3, encoded by the CASP3 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-3 is a central player in mediating apoptosis and is the most widely studied caspase. This protein cleaves and activates caspases 6, 7 and 9, and itself can be processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of the CASP3 gene results in two transcript variants which encode the same protein. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0291573) =Amino Acid, Peptide, or Protein; Enzyme
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- 3. Apo E
- [prominent protein constituents of plasma VLDL, chylomicrons, and a subfraction of HDL as well as of remnant lipoproteins which are derived from the lipoprotein lipase-mediated intravascular catabolism of triglyceride-rich lipoproteins; recognized by the LDL receptor and Apo E receptor; any defect in the Apo E metabolism leads to increased plasma Apo E levels; a strong association has been found between high levels of Apo E and type III hyperlipoproteinemia. ( CSP )] (UMLS (CSP) C0003595) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 26. apophysis ossium
- [ ] (UMLS (CSP) C0872099) =Body Part, Organ, or Organ Component ;
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- 4. APO-1 Cell Surface Antigen
- [differentiation antigens expressed on a variety of cell lines; regulate peripheral immune responses. ( CSP )] (UMLS (NCI) C0245662) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
| - 27. apoplipoprotein AI
- [ ] (UMLS (CSP) C0872100) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 5. APO1 antigen
- [ ] (UMLS (CSP) C0599661) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 28. apoptosis
- [(ap-o-TOE-sis) A normal series of events in a cell that leads to its death. ( NCI )] (UMLS (NCI) C0162638) =Cell Function ;
=cell death;
Cellular Biology |
- 6. APO2 Ligand
- [Tumor Necrosis Factor Ligand Superfamily Member 10, encoded by the TNFSF10 Gene, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of cells. It preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. (From LocusLink, OMIM and NCI) ( NCI )] (UMLS (NCI) C0385242) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 29. Apoptosis Antigen Ligand 1
- [FAS ligand is a TNF family, type II transmembrane protein expressed on many cell types and secreted from T-cells upon TCR ligation by MHC/peptide complexes residing on antigen presenting cells. FAS ligand triggers cell death by binding to the cell surface receptor FAS, another transmembrane protein member of the TNF receptor family. FAS ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T-cell-mediated cytotoxicity, and in the liver, lung, ovary, and heart, where its function is unclear. (from OMIM 134638 and NCI) ( NCI )] (UMLS (NCI) C0253023) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 7. Apocrine Adenoma
- [A benign epithelial neoplasm arising from the apocrine sweat glands. Representative examples include tubular apocrine adenoma and external auditory canal ceruminous adenoma. ( NCI )] (UMLS (NCI) C0334345) =Neoplastic Process
| - 30. Apoptosis Inducing Protein TRICK2A/2B
- [Receptor for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) ( NCI )] (UMLS (NCI) C0664123) =Amino Acid, Peptide, or Protein; Receptor ;
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- 8. Apocrine Adenosis of Breast
- (UMLS (NCI) C1332314) Apocrine Adenosis of the Breast;
Breast Apocrine Adenosis;
=Disease or Syndrome ;
| - 31. Apoptosis Induction
- [Mechanisms involved in Induction of Apoptosis initiate biochemical processes, often enzymatic cascades, that promote programmed cell death. ( NCI )] (UMLS (NCI) C1326205) Induction of Apoptosis;
=Cell Function |
- 9. Apocrine Breast Carcinoma
- [An adenocarcinoma of the breast characterized by the presence of two intermingled cellular components: cells with abundant granular, eosinophilic cytoplasm, and cells with abundant cytoplasm containing fine empty vacuoles. ( NCI )] (UMLS (NCI) C1332316) Apocrine Carcinoma of Breast;
Apocrine Carcinoma of the Breast;
Breast Apocrine Carcinoma =Neoplastic Process ;
| - 32. Apoptosis Inhibitor
- [Encoded by Apoptosis Inhibitor Genes, Apoptosis Inhibitor proteins impede the initiation, progress, or rate of apoptosis. ( NCI )] (UMLS (NCI) C1332320) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 10. Apocrine Breast Carcinoma In Situ
- (UMLS (NCI) C1332315) Apocrine Carcinoma in situ of Breast;
Apocrine Carcinoma in situ of the Breast;
Breast Apocrine Carcinoma in situ =Neoplastic Process ;
| - 33. Apoptosis Inhibitor 2
- [Encoded by BIRC3 Gene (IAP Family) Baculoviral IAP Repeat-Containing Protein 3 inhibits apoptosis by binding to TNF Receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring-type zinc finger domain while the Zn binding domain is involved in protein-protein interactions in caspase inhibition and spindle assembly. BIRC3 is present in many fetal and adult tissues and mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. ( NCI )] (UMLS (NCI) C0763658) Baculoviral IAP Repeat-Containing Protein 3;
BIRC3;
Cellular Inhibitor of Apoptosis-2;
Human Inhibitor of Apoptosis Protein-1;
Mammalian IAP Homolog C;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 11. Apocrine Metaplasia
- (UMLS (NCI) C0334036) =Neoplastic Process
| - 34. Apoptosis Inhibitor 3
- [Encoded BIRC4 Gene (IAP Family), Baculoviral IAP Repeat-Containing Protein 4 inhibits apoptosis through binding to TNF Receptor-associated factors TRAF1 and TRAF2. Similar to BIRC2, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also specifically inhibits cell-death proteases, caspase-3 and caspase-7. A novel transcript homologous to BIRC4 is expressed solely in the testis. ( NCI )] (UMLS (NCI) C1173600) Baculoviral IAP Repeat-Containing Protein 4;
BIRC4;
IAP-Like Protein;
X-linked Inhibitor of Apoptosis =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 12. Apocrine Metaplasia of Breast
- (UMLS (NCI) C0269252) =Disease or Syndrome
| - 35. Apoptosis Inhibitor Gene
- [Apoptosis Inhibitor Genes encode Apoptosis Inhibitor proteins, which impede the initiation, progress, or rate of apoptosis. ( NCI )] (UMLS (NCI) C1332321) =Gene or Genome ;
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- 13. Apocrine Neoplasm
- (UMLS (NCI) C1332318) Apocrine Neoplasm of Skin;
Apocrine Neoplasm of the Skin;
Apocrine Skin Neoplasm;
Apocrine Skin Tumor;
Apocrine Tumor;
Apocrine Tumor of Skin;
Apocrine Tumor of the Skin =Neoplastic Process ;
| - 36. Apoptosis Promoter
- [Encoded by Apoptosis Promoter Genes, Apoptosis Promoter proteins promote the initiation, progress, or rate of apoptosis. ( NCI )] (UMLS (NCI) C1332322) Inducer of Apoptosis =Amino Acid, Peptide, or Protein ;
|
- 14. Apocrine Sweat Gland
- (UMLS (NCI) C0930083) =Body Part, Organ, or Organ Component
| - 37. Apoptosis Promoter Gene
- [Apoptosis Promoter Genes encode Apoptosis Promoter proteins, which promote the initiation, progress, or rate of apoptosis. ( NCI )] (UMLS (NCI) C1332323) =Gene or Genome ;
|
- 15. Apocrine Sweat Gland Hamartoma
- (UMLS (NCI) C1332319) Hamartoma of Apocrine Sweat Gland;
Hamartoma of the Apocrine Sweat Gland;
=Disease or Syndrome ;
| - 38. Apoptosis Regulation Gene
- [Apoptosis Regulation Genes encode Apoptosis Regulator proteins, which either promote or impede the initiation, progress, or rate of apoptosis. ( NCI )] (UMLS (NCI) C1332324) =Gene or Genome ;
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- 16. Apoda
- [ ] (UMLS (CSP) C0597830) =Amphibian
| - 39. Apoptosis Regulator
- [Encoded by Apoptosis Regulation Genes, Apoptosis Regulator proteins either promote or impede the initiation, progress, or rate of apoptosis. ( NCI )] (UMLS (NCI) C1332325) Regulator of Apoptosis =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 17. apoenzyme
- [protein components of the enzyme minus any cofactors or prosthetic groups that might be required for the enzyme to be catalytically functional. ( CSP )] (UMLS (CSP) C0003589) =Amino Acid, Peptide, or Protein; Enzyme
| - 40. Apoptosis Regulator BAK
- [A BCL2 related protein that induces apoptosis. May cause the mitochondrial voltage-dependent anion channel to open and release cytochrome c into the cytoplasm resulting in caspase activation. (from RefSeq Summary) ( NCI )] (UMLS (NCI) C0296517) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 18. apolipoprotein
- [protein components of lipoproteins which remain after the lipids to which the proteins are bound have been removed; they play an important role in lipid transport and metabolism. ( CSP )] (UMLS (CSP) C0003591) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 41. Apoptosis Regulator BCL-W
- [This protein is a member of the BCL-2 protein family. Expression of this protein in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. (from RefSeq Summary) ( NCI )] (UMLS (NCI) C1332395) BCL2 Like 2;
BCL2L2;
BCL2L2 Protein;
BCL2-Like 2;
BCL2-Related 2 Protein;
BCLW;
BCL-W;
KIAA0271;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 19. apolipoprotein J
- [a widely distributed glycoprotein with a diverse set of biologic actions, the most prominent of which is its ability to promote cell interactions; another unique feature is its induction at times of tissue injury and remodeling. ( CSP )] (UMLS (CSP) C0055966) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=apolipoprotein;
glycoprotein | - 42. Apoptosis Response Protein
- [Apoptosis Response Protein, encoded by the PAWR gene, is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. Apoptosis Response Protein is specifically upregulated during apoptosis of prostate cells. (from LocusLink) ( NCI )] (UMLS (NCI) C0529535) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 20. Apolizumab/Rituximab
- (UMLS (NCI) C1134497) =Therapeutic or Preventive Procedure
| - 43. Apoptosis-Inducing NBK
- [This protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2, BCLXL, Epstein-Barr virus BHRF1, and adenovirus E1B 19-kD in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. (from RefSeq Summary and OMIM) ( NCI )] (UMLS (NCI) C1332394) BCL2-Interacting Killer;
BIK;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 21. Apollon
- [Baculoviral IAP Repeat-Containing Protein 6, encoded by the BIRC6 gene, is a member of the IAP (inhibitors of apoptosis proteins) family and the ubiquitin-conjugating enzyme family. This protein is expressed as a 530-kD protein in gliomas and ovarian cancers. BIRC6 may protect cancer cells from undergoing apoptosis and resist to apoptosis in the presence of anticancer drugs. BIRC6 contains a 70-amino acid cysteine- and histidine-rich baculovirus IAP repeat (BIR) and a zinc-binding RING finger. ( NCI )] (UMLS (NCI) C0910612) Baculoviral IAP Repeat-Containing Protein 6;
BIRC6;
KIAA1289;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 44. Apoptotic Cysteine Protease MCH2
- [Caspase-6, encoded by the CASP6 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-6 can be processed by caspases 7, 8 and 10, and functions as a downstream enzyme in the activation cascade of caspases responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Alternative splicing of this gene results in two transcript variants which encode different isoforms. Its overexpression promotes programmed cell death. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0538091) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 22. Apomine
- (UMLS (NCI) C0919349) =Organic Chemical; Pharmacologic Substance ;
| - 45. Apoptotic Protease Mch-3
- [Caspase-7, encoded by the CASP7 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase can be cleaved by caspase 3 and 10. It has been shown to be activated upon cell death stimuli and induce apoptosis. Alternative splicing of this gene results in 4 transcript variants, which encode 3 distinct isoforms. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0537969) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 23. apomorphine
- [derivative of morphine that is a dopamine D2 agonist; a powerful emetic useful in acute poisoning; has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. ( CSP )] (UMLS (CSP) C0003596) =Organic Chemical; Pharmacologic Substance
| - 46. aporphine
- [Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES). ( MSH )] (UMLS (CSP) C0003606) =Organic Chemical ;
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