- 1. Bag
- (UMLS (HL7) C1552653) =Idea or Concept =ParameterizedDataType;
◊ (UMLS (HL7) C1552710) Idea or Concept ANY; Bag Of Concept Descriptors; Bag Of Physical Quantities | - 6. BAG1
- [Encoded by human BAG1 Gene as isoforms 1 (274-aa, 31-kD) and 2 (240-aa), acidic (pI 5.3) glutamate-rich BAG1 Protein contains a Ubiquitin-like domain and BAG domain. BAG1 may link growth factor receptor and anti-apoptotic signal transduction mechanisms. The C-terminal region interacts with HGFR and PDGFR, but the entire protein is required for anti-apoptotic activity. BAG1 stimulates anti-apoptotic membrane protein BCL2. It also binds to NR3C1 and appears to interact with RAF1 Ser/Thr protein kinase, which promotes BCL2 activity. Bound to the HSP70/HSC70 ATPase domain, BAG1 inhibits chaperone activity by promoting substrate release. BAG1 may suppress GADD34-mediated stress responses, have a role in cell survival, and be involved in developmental processes that require cell death. ( NCI )] (UMLS (NCI) C0379646) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 2. Bag
- [A pouched or pendulous container. ( HL7V3.0 )] (UMLS (HL7) C1561600) =Intellectual Product =NonRigidContainerEntityType;
| - 7. BAG1
- [This gene plays a role in signal transduction and is involved in the negative regulation of apoptosis. ( NCI )] (UMLS (NCI) C1332371) BAG1 Gene;
BCL2-Associated Athanogene Gene =Gene or Genome ;
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- 3. Bag
- [A sac or pouch. ( NCI )] (UMLS (NCI) C0179196) =Manufactured Object
| - 8. BAG4
- [This gene plays a role in receptor signaling and the inhibition of apoptosis. ( NCI )] (UMLS (NCI) C1332372) BAG4 Gene;
BCL2-Associated Athanogene 4 Gene =Gene or Genome ;
◊ [This protein is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. (LocusLink) ( NCI )] (UMLS (NCI) C1332392) BAG-Family Molecular Chaperone Regulator-4; BCL2-associated Athanogene 4; Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 4. Bag Of Concept Descriptors
- (UMLS (HL7) C1552711) =Idea or Concept =Bag;
| - 9. BAG5
- [This gene is involved in signal transduction and regulation of apoptosis. ( NCI )] (UMLS (NCI) C1332373) BAG5 Gene;
BCL2-Associated Athanogene 5 Gene =Gene or Genome ;
◊ [Encoded by human BAG5 Gene (BAG1 Family), 447-aa 52-kD BCL2-associated Athanogene 5 contains 4 bag domains and, bound to HSP70/HSC ATPase domains, inhibits HSP70/HSC70 chaperone activity by promoting substrate release. A BAG domain near the C-terminus may bind HSC70/HSP70. ( NCI )] (UMLS (NCI) C1332393) BAG-Family Molecular Chaperone Regulator-5; BCL2-associated Athanogene 5; Amino Acid, Peptide, or Protein ; |
- 5. Bag Of Physical Quantities
- (UMLS (HL7) C1552712) =Idea or Concept =Bag;
| - 10. bagassosis
- [ ] (UMLS (CSP) C0004681) =Disease or Syndrome ;
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