- 1. CD1 antigen
- [antigen presenting molecule encoded outside of the major histocompatibility complex. ( CSP )] (UMLS (CSP) C0054941) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=CD antigen;
| - 12. CD127
- [This protein is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). It has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink) ( NCI )] (UMLS (NCI) C0083032) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 2. CD102
- [CD102. Intracellular Adhesion Molecule-2. ( NCI )] (UMLS (NCI) C1317964) CD102 Antigen;
ICAM2;
ICAM-2;
Intercellular Adhesion Molecule 2 =Amino Acid, Peptide, or Protein; Immunologic Factor | - 13. CD132
- [The interleukin 2 (IL2) receptor gamma chain (IL2RG) is an important signalling component of many interleukin receptors (e.g., IL2,IL4,IL7,IL9, and IL15) and is thus referred to as the common gamma chain. It is necessary for normal growth and differentiation of T cells, B cells, natural killer cells, glioma cells, and cells of the monocyte lineage. Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). (from LocusLink and OMIM) ( NCI )] (UMLS (NCI) C1334204) Common Cytokine Receptor Gamma Chain;
Common Gamma Chain;
IL2RG;
Interleukin 2 Receptor Gamma;
Interleukin 2 Receptor, Gamma;
Interleukin 2 Receptor, Gamma Chain =Amino Acid, Peptide, or Protein; Receptor ;
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- 3. CD105
- [Endoglin is a Transforming Growth Factor Receptor present on tumor vasculature. It is a marker of angiogenesis and a target for cancer therapy. ( NCI )] (UMLS (NCI) C0082420) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 14. CD14
- [CD antigen expressed on surface of monocytes, macrophages, eosinophils, neutrophils; lipopolysaccharide receptor; signals production of tumor necrosis factor. ( CSP )] (UMLS (NCI) C0108768) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
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- 4. CD106
- [cytokine induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts and myotubes; important for the recruitment of leukocytes to sites of inflammation. ( CSP )] (UMLS (CSP) C0078056) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=Adhesion Molecule;
| - 15. CD14
- [This gene plays a role in apoptosis and in ligand-binding interactions. ( NCI )] (UMLS (NCI) C1367477) CD14 Antigen Gene;
CD14 Gene =Gene or Genome |
- 5. CD11
- [A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95. ( MSH )] (UMLS (CSP) C0054942) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 16. CD148
- [Expressed in all hematopoietic lineages by human PTPRJ Gene (PTP Family), 1337-aa 146-kDa (precursor) N- and O-glycosylated type I membrane Protein Tyrosine Phosphatase Receptor Type J is a receptor-type PTP with an extracellular region containing 9 fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic PTP catalytic domain. PTPRJ negatively regulates TCR signaling, possibly by interfering with phosphorylation of PLCG1 and LAT. PTPRJ also dephosphorylates the PDGF beta receptor, may be involved in UV-induced signal transduction, and may contribute to contact inhibition of cell growth. Defects in PTPRJ are found in cancers of colon, lung, and breast. (NCI) ( NCI )] (UMLS (NCI) C0289499) =Amino Acid, Peptide, or Protein; Enzyme ;
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- 6. CD110
- [MPL encodes the Thrombopoietin Receptor, a member of the cytokine receptor superfamily. The mechanism by which TPO activates the TPOR appears similar to that of other hematopoietic cytokines that bind and induce receptor homodimerization. TPO regulates the production of multipotent hematopoietic progenitor cells and platelets. Lymphoid progenitors express IL7R and not MPL, whereas myeloid progenitors express MPL and not IL7R. The receptor for thrombopoietin may also represent a regulatory molecule specific for TPOR-dependent immune responses. TPOR contains two fibronectin type III-like domains and is a type I membrane protein. Two isoforms, MPL-K and MPL-P, are produced by alternative splicing and are co-expressed. (from OMIM 159530, SWISS-PROT P40238, and NCI) ( NCI )] (UMLS (NCI) C0218227) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 17. CD152
- [CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells. It contains an extracellular V-like domain, a transmembrane region, and a putative cytoplasmic domain. It shares significant homology with CD28. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation. A CTLA-4 splice variant with a deleted transmembrane segment is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. CTLA-4 may play an inhibitory role in regulating lymphocyte expansion. (from OMIM 123890 and NCI) ( NCI )] (UMLS (NCI) C0111208) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
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- 7. CD115
- [Colony stimulating factor-1 receptor protein (972 aa, ~108 kDa) is encoded by the c-fms proto-oncogene (CSF1R Gene). The protein is a transmember receptor for colony-stimulating factor and has tyrosine kinase activity. ( NCI )] (UMLS (NCI) C0080092) =Amino Acid, Peptide, or Protein; Enzyme; Immunologic Factor; Receptor
| - 18. CD154
- [A cell surface marker on T-cells. A member of the TNF family. It regulates B cell function by engaging CD40 on the B cell surface. ( NCI )] (UMLS (NCI) C0167627) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
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- 8. CD119
- [Expressed in monocytes, lymphocytes, and placenta by human IFNGR1 Gene (Type II Cytokine Receptor Family), monomeric 489-aa 90-kDa type I membrane protein Interferon Gamma Receptor Alpha Chain is a subunit of Ser/Thr phosphorylated heteromeric Interferon Gamma Receptor Complex, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. Containing an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several potential Ser- and Thr-rich O-linked glycosylation sites, 2 fibronectin type III domains, 2 Ig-like C2-type domains, a transmembrane domain, and a cytoplasmic portion, IFNGR1 acts as the receptor ligand-binding subunit. IFNGR2 constitutes an integral receptor accessory factor required for signal transduction. Defects in IFNGR1 are a cause of FDAMI. (NCI) ( NCI )] (UMLS (NCI) C1334195) CD119 Antigen;
CDw119;
IFN-Gamma-R1;
Immune Interferon Receptor;
Interferon Gamma Receptor Alpha Chain;
Interferon Gamma Receptor-1 =Amino Acid, Peptide, or Protein; Receptor ;
| - 19. CD16
- [expressed on natural killer cells, granulocytes, and monocytes; its gene has been mapped to chromosome 1. ( CSP )] (UMLS (NCI) C0108747) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor =CD antigen;
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- 9. CD122
- [This protein is the beta subunit of the interleukin 2 receptor and is a type I membrane protein. It is involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. It plays a role in the T cell mediated immune response and is a member of the cytokine receptor family. (from LocusLink) ( NCI )] (UMLS (NCI) C1173313) IL2RB;
Interleukin 2 Receptor Beta;
Intermediate Affinity Interleukin 2 Receptor;
Medium Affinity Interleukin 2 Receptor;
P70-75;
=Amino Acid, Peptide, or Protein; Receptor ;
| - 20. CD16
- [Expressed (as NA-1, NA-2, and SH allelic forms) specifically by neutrophils and stimulated eosinophils, human FCGR3B Gene encodes 233-aa 26-kDa (precursor) monomeric IgG Fc Receptor IIIB, a glycosylated (inhibits IgG3 interaction) low affinity receptor for monomeric or aggregated Fc region of IgG, attached to membrane by a GPI-anchor, and containing 2 IgC2 domains. FCGR3B also exists as a soluble receptor produced by proteolytic cleavage. Unlike FCGR3A, FCGR3B is not capable of mediating antibody-dependent cytotoxicity and phagocytosis; FCGR3B may serve as a trap for immune complexes in the peripheral circulation without activating neutrophils. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI) ( NCI )] (UMLS (NCI) C0966831) CD16B;
Fc Receptor III-1;
FCG3;
Fc-Gamma RIII;
Fc-Gamma RIIIB;
Fc-Gamma RIII-Beta;
FCGR3;
FCGR3B;
FcR-10;
FcRIII;
FcRIIIB;
IgG Fc Receptor IIIB;
Low Affinity IgG Fc Receptor IIIB;
Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B;
=Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor |
- 10. CD123
- [Encoded by human IL3RA Gene (Type I Cytokine Receptor 5 Family), 378-aa 43-kDa (precursor) Interleukin 3 Receptor Alpha is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the ligand-binding alpha subunit of a heterodimeric cytokine receptor for Interleukin 3. Receptor binding to IL3 depends on the signal transducing beta subunit, shared by IL3-, IL5-, and CSF2/GM-CSF receptors. (NCI) ( NCI )] (UMLS (NCI) C0758637) CD123 Antigen;
IL3R;
IL3RA;
IL3R-Alpha;
IL3RX;
Interleukin 3 Receptor;
Interleukin 3 Receptor Alpha;
Interleukin 3 Receptor Alpha Chain;
Low Affinity Interleukin 3 Receptor Alpha =Amino Acid, Peptide, or Protein; Receptor ;
| - 21. CD161
- [Encoded by human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) and preferentially expressed by natural killer lymphocytes and some peripheral T-cells, the type II membrane NKRP1A Protein (external C-terminus) contains a 158-amino acid extracellular domain with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid cytoplasmic domain. C-type lectins, including NKRP1 glycoproteins, may regulate NK cell function. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical to human NKG2A. (from LocusLink, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0132638) =Amino Acid, Peptide, or Protein; Immunologic Factor
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- 11. CD124
- [IL4R when complexed with the common gamma chain (IL2RG) serves as the high-affinity interleukin 4 (IL4) receptor. It plays a major role in immunoglobulin E (IgE) production. ( NCI )] (UMLS (NCI) C0123771) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 22. CD19
- [This gene plays a role in signal transduction and regulates the response of B cells to antigens. ( NCI )] (UMLS (NCI) C1413206) CD19 Antigen Gene;
CD19 Gene =Gene or Genome |
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