[Encoded by human RAP1A Gene (RAS GTPase Family), 184-aa 21-kDa (precursor) membrane-bound RAS-Related Protein RAP1A is activated by guanine nucleotide-exchange factors EPAC and EPAC2, in a cAMP-dependent manner, and by GFR. Interacting with RAS GAPs and RAF in a competitive manner, RAP1A counteracts RAS mitogenic function. (NCI) ( NCI )] (UMLS (NCI) C0967718) G-22K; GTP-Binding Protein SMG-P21A; KREV-1 Protein; RAP1A; RAP1A Member of RAS Oncogene Family; RAS-Related Protein RAP1A; SMGP21 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;