- 1. CLG
- [Encoded by human MMP1 Gene (M10A Peptidase Family), 469-aa 54-kDa (precursor) secreted zinc- and calcium-binding Matrix Metalloproteinase-1 contains a hemopexin-like domain, an N-terminal catalytic domain, and a C-terminal substrate- and TIMP-binding domain. MMP1 undergoes autolytic cleavage to major forms 27-kDa (inactive) and 22-kDa (a collagenase activator). MMP1 preferentially cleaves interstitial collagens types I, II, and III at one site in the triple helical domain. MMP1 also cleaves collagens types VII and X and alpha-macroglobulins. (NCI) ( NCI )] (UMLS (NCI) C0127082) =Amino Acid, Peptide, or Protein; Enzyme
| - 2. CLG1
- [Expressed in neutrophils by human MMP8 Gene (M10A Peptidase Family), 467-aa 53-kDa (precursor) zinc- and calcium-binding Matrix Metalloproteinase-8 contains a hemopexin-like domain and is stored in secondary granules. Activated by autolytic cleavage, MMP8 degrades fibrillar type I, II, and III interstitial collagens by cleavage in the triple helical domain. (NCI) ( NCI )] (UMLS (NCI) C0172956) =Amino Acid, Peptide, or Protein; Enzyme ;
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