- 1. cofactor
- [any nonprotein substance required by a protein for biological activity, such as prosthetic groups of coenzymes, which are not consumed in the process and are found unchanged at the end of the reaction. ( CSP )] (UMLS (CSP) C0178555) =Biologically Active Substance ;
=Chemical; =(+)-Biotin; coA; FAD; flavin mononucleotide; dihydronicotinamide adenine dinucleotide; NAD phosphate; creatine phosphate; pyridoxal phosphate; cocarboxylase; 2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecanyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione; tetrahydrofolate; adenosylcobalamin | - 11. Cofactor Required for Sp1 Transcriptional Activation, Subunit 3, 130kDa Gene
- [This gene is involved in activation of Sp1 transcription. It also plays a role in suppression of metastasis. ( NCI )] (UMLS (NCI) C1332782) CRSP3;
CRSP3 Gene =Gene or Genome |
- 2. Cofactor Required for SP1 Activation
- [A protein complex, which, along with TFIID, is required for efficient transcriptional activation by SP1. ( NCI )] (UMLS (NCI) C1333076) CRSP Complex;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 12. Cofactor Required for Sp1 Transcriptional Activation, Subunit 4, 100kDa Gene
- [This gene plays a role in the transcriptional activation of Sp1. ( NCI )] (UMLS (NCI) C1332783) CRSP4;
CRSP4 Gene =Gene or Genome |
- 3. Cofactor Required for Sp1 Transcriptional Activation Subunit 2
- [Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP2 gene at Xp11.4-p11.2 encodes a 150-kD protein that is subunit 2 of the CRSP complex. This CRSP2 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. CRSP2 contains a cytochrome C family heme-binding motif and a bipartite nuclear localization signal. (from OMIM 300182, LocusLink 9282) ( NCI )] (UMLS (NCI) C1313003) CRSP2 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 13. Cofactor Required for Sp1 Transcriptional Activation, Subunit 6, 77kDa Gene
- [This gene is involved in coactivation of Sp1 transcription. It also plays a role in vitamin D and thyroid hormone binding. ( NCI )] (UMLS (NCI) C1332784) CRSP6;
CRSP6 Gene =Gene or Genome |
- 4. Cofactor Required for Sp1 Transcriptional Activation Subunit 3
- [Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation) along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP3 gene encodes this 130-kD protein that is subunit 3 of the CRSP complex. The CRSP3 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. (from OMIM 605042, LocusLink 9439) ( NCI )] (UMLS (NCI) C1313004) CRSP3 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 14. Cofactor Required for Sp1 Transcriptional Activation, Subunit 7, 70kDa Gene
- [This gene plays a role in the activation of Sp1 transcription. ( NCI )] (UMLS (NCI) C1332785) CRSP7;
CRSP7 Gene =Gene or Genome |
- 5. Cofactor Required for Sp1 Transcriptional Activation Subunit 4
- [Encoded by human CRSP4 Gene, Cofactor Required for Sp1 Transcriptional Activation Subunit 4 is 100-kD protein of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI) ( NCI )] (UMLS (NCI) C1313005) CRSP100;
CRSP4; =Amino Acid, Peptide, or Protein; Biologically Active Substance ; | - 15. Cofactor Required for Sp1 Transcriptional Activation, Subunit 8, 34kDa Gene
- [This gene is involved in the transcriptional activation of Sp1. ( NCI )] (UMLS (NCI) C1332786) CRSP8;
CRSP8 Gene =Gene or Genome |
- 6. Cofactor Required for Sp1 Transcriptional Activation Subunit 6
- [Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. ( NCI )] (UMLS (NCI) C1313007) CRSP6 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 16. Cofactor Required for Sp1 Transcriptional Activation, Subunit 9, 33kDa Gene
- [This gene plays a role in coactivation of Sp1 transcription. ( NCI )] (UMLS (NCI) C1332787) CRSP9;
CRSP9 Gene =Gene or Genome |
- 7. Cofactor Required for Sp1 Transcriptional Activation Subunit 7
- [Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. ( NCI )] (UMLS (NCI) C1313008) CRSP7;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ; | - 17. coffee
- [widely consumed beverage made from roasted and ground seeds of Coffea plants infused in hot water; generally contains caffeine and theophylline unless it is decaffeinated. ( CSP )] (UMLS (CSP) C0009237) =Food =beverage;
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- 8. Cofactor Required for Sp1 Transcriptional Activation Subunit 8
- [Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP8 gene encodes this 34-kD protein that is subunit 8 of the CRSP complex. The CRSP8 protein is required for Sp1-mediated transcriptional activation with TAF(II)s. (from OMIM 605044, LocusLink 9442) ( NCI )] (UMLS (NCI) C1313009) CRSP8;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ; | - 18. Coffin-Siris Syndrome
- (UMLS (NCI) C0265338) =Congenital Abnormality; Disease or Syndrome
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- 9. Cofactor Required for Sp1 Transcriptional Activation Subunit 9
- [Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP9 gene encodes this 33-kD protein that is subunit 9of the CRSP complex. The CRSP9 protein is required with the TAF(II)s for Sp1-mediated transcriptional activation. (from OMIM 605045, LocusLink 9443) ( NCI )] (UMLS (NCI) C1313010) CRSP9;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ; | - 19. cofilin
- [ ] (UMLS (CSP) C0056080) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 10. Cofactor Required for Sp1 Transcriptional Activation, Subunit 2, 150kDa Gene
- [This gene plays a role in activation of Sp1 transcription. It is also involved in vitamin D and thyroid hormone binding. ( NCI )] (UMLS (NCI) C1332781) CRSP2;
CRSP2 Gene =Gene or Genome | |