- 1. CTL
- [antibody-independent "killer cells" derived from the CD8 T lymphocyte line which, when stimulated by antigen, MHC class I antigen, and interleukin 2, secrete cytolytic pore-forming proteins capable of lysing target cells. ( CSP )] (UMLS (NCI) C0039195) =Cell =K cell;
T Cell =Lymphocytes, Tumor-Infiltrating;
| - 4. CTLA4
- [This gene is involved in T-cell mediation and receptor signal transduction. ( NCI )] (UMLS (NCI) C1332802) CTLA4 Gene;
Cytotoxic T-Lymphocyte-Associated Protein 4 Gene =Gene or Genome |
- 2. CTL A4-Ig B7 Inhibitor
- [A human fusion protein with immunosuppressive activity. It consists of the binding domain of human cytotoxic T-lymphocyte-associated antigen 4 and human IgG1. CTLA4-Ig works by binding to CD80 and CD86 on antigen presenting cells, thereby blocking the engagement of CD28 on T-cells, a co-stimulatory signal required for full T-cell activation. This co-stimulatory blocker prevents T-cell activation, and proliferation, and subsequent cytokine production. This T-cell regulatory protein may be useful in treating autoimmune diseases such as rheumatoid arthritis, and may help prevent organ transplant rejection. ( NCI )] (UMLS (NCI) C1172366) CTLA4-Ig;
cytotoxic T lymphocyte-associated antigen-4 =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 5. CTLA8
- [Interleukin-17, encoded by the IL17 gene, is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (From LocusLink) ( NCI )] (UMLS (NCI) C0384648) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
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