- 1. CYP
- [hemeproteins whose characteristic mode of action involves transfer of reducing equivalents which are associated with a reversible change in oxidation state of the prosthetic group; the various cytochrome subclasses are organized by the type of heme and by the wavelength range of their reduced alpha-absorption bands. ( CSP )] (UMLS (NCI) C0010798) =Amino Acid, Peptide, or Protein; Biologically Active Substance =heme protein;
=cytochrome b;
cytochrome c;
CYP (cytochrome P450);
cytochrome b2 | - 20. CYP2D5
- [Cytochrome P450 2D5 is a rat liver ER membrane-bound heme-thiolate monooxygenase, involved in an NADPH-dependent electron transport pathway that oxidizes various compounds, including steroids, fatty acids, and xenobiotics. Expression is induced in liver and other tissues by drugs, pesticides, and carcinogens. ( NCI )] (UMLS (NCI) C1333193) Cytochrome P450 2D5 =Amino Acid, Peptide, or Protein; Enzyme
|
- 2. CYP (cytochrome P450)
- [superfamily of closely related heme enzymes found throughout the phylogenetic spectrum; they catalyze the insertion of an atom of oxygen into substrates; in animals, these P-450 enzymes are involved in biosynthesis of steroids, fatty acids, and bile acids and also in metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. ( CSP )] (UMLS (CSP) C0010762) =Amino Acid, Peptide, or Protein; Enzyme =CYP;
Enzymes, Coenzymes, and Enzyme Inhibitors =aryl 4 monooxygenase;
CYP3A;
CPB6;
CYP 2C9;
CYP 2C;
CYP 2C19;
CYP 2C18;
CYP 3A3/4;
CYP 3A5-7;
CYP 2C8 | - 21. CYP2D6
- [This gene plays a role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of xenobiotics. ( NCI )] (UMLS (NCI) C1332830) CYP2D6 Gene;
Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Gene =Gene or Genome |
- 3. CYP11A1
- [This gene is involved in steroid metabolism. ( NCI )] (UMLS (NCI) C1413855) CYP11A1 Gene;
Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 Gene =Gene or Genome | - 22. CYP2E1
- [This gene is involved in the metabolism of both endogenous and exogenous substrates. ( NCI )] (UMLS (NCI) C0919426) CYP2E1 Gene;
Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Gene =Gene or Genome ;
|
- 4. CYP11B1
- [Encoded by human CYP11B1 Gene (Cytochrome P450 Family), 503-aa 58-kDa (precursor) Cytochrome P450 CYP11B1 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase expressed in adrenal cortex with steroid 11-beta-hydroxylase activity and involved in conversion of progesterone to cortisol. The 18 or 19-hydroxylation of steroids and aromatization of androstendione to estrone have also been ascribed to CYP11B1. CYP11B1 defects cause adrenal hyperplasia type IV (AH-IV). CYP11B1/CYP11B2 gene fusion causes glucocorticoid-remediable aldosteronism (GRA). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI) ( NCI )] (UMLS (NCI) C0038296) =Amino Acid, Peptide, or Protein; Enzyme =Oxygenase;
| - 23. CYP3A4
- [Induced primarily in liver by glucocorticoids, drugs, pesticides, and carcinogens and encoded by human CYP3A4 Gene (Cytochrome P450 IIIA Subfamily), Cytochrome P450 3A4 is a 502-amino acid 57.3-kD membrane-bound ER heme-thiolate monooxygenase. CYP3A4 is involved in an NADPH-dependent electron transport pathway and phase I oxidative metabolism of carcinogens, steroids, fatty acids, and xenobiotics, as well as bioactivation of aflatoxin B(1) to a genotoxic derivative. Activity seems a key predictor of drug responsiveness and toxicity. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1142644) Cytochrome P450 3A4;
Cytochrome P450 Nifedipine Oxidase;
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3;
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4;
Cytochrome P450, Subfamily IIIA, Polypeptide 4;
Cytochrome P450PCN1;
EC 1.14.14.1;
Glucocorticoid-Inducible P450;
Nifedipine Oxidase;
P450, FAMILY III;
P450-3A4;
P450-III, Steroid Inducible;
P450-III, Steroid-Inducible;
Quinine 3-Monooxygenase;
Steroid-Inducible P450- III =Amino Acid, Peptide, or Protein; Enzyme |
- 5. CYP11B1
- [This gene plays a role in the metabolism of glucucorticoids. ( NCI )] (UMLS (NCI) C1413856) CYP11B1 Gene;
Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 Gene =Gene or Genome | - 24. CYP3A4
- [This gene plays an role in the metabolism of numerous clinically-relevant drugs. It is also involved in the oxidation of both endogenous substrates and xenobiotics. ( NCI )] (UMLS (NCI) C1176140) CYP3A4 Gene;
Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene =Gene or Genome ;
|
- 6. CYP11B2
- [This gene is involved in mineralocorticoid metabolism. ( NCI )] (UMLS (NCI) C1413857) CYP11B2 Gene;
Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 Gene =Gene or Genome | - 25. CYP3A5
- [This gene is involved in the metabolism of fatty acids, steroids, drugs and xenobiotics. It also plays a role in the metabolism of sex hormones. ( NCI )] (UMLS (NCI) C1413882) CYP3A5 Gene;
Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 Gene =Gene or Genome |
- 7. CYP17A1
- [Encoded by human CYP17A1 Gene (Cytochrome P450 Family), 508-aa 57-kDa Cytochrome P450 XVIIA1 is a cAMP-regulated endoplasmic reticulum P450 heme-thiolate monooxygenase with 17alpha-hydroxylase and 17,20-lyase activity and a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Involved in fetal and adult sexual development, CYP17A1 converts pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. CYP17A1 mutations are associated with steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia type V (AH-V). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI) ( NCI )] (UMLS (NCI) C0038302) =Amino Acid, Peptide, or Protein; Enzyme =Oxygenase;
| - 26. CYP3A7
- [This gene plays a role in the metabolism of drugs, xenobiotics, fatty acids and steroids. It is also involved in the synthesis of estriol during pregnancy. ( NCI )] (UMLS (NCI) C1413884) CYP3A7 Gene;
Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 Gene =Gene or Genome |
- 8. CYP17A1
- [This gene plays a role in the metabolism of estrogen and glucocorticoids. It is also involved in sexual maturation. ( NCI )] (UMLS (NCI) C1413858) CYP17A1 Gene;
Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 Gene =Gene or Genome | - 27. CYP7A1
- [This gene is involved in bile acid synthesis and steroid metabolism. ( NCI )] (UMLS (NCI) C1413893) CYP7A1 Gene;
Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 Gene =Gene or Genome |
- 9. CYP19A1
- [This gene is involved in development and estrogen metabolism. ( NCI )] (UMLS (NCI) C1366496) CYP19A1 Gene;
Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Gene =Gene or Genome | - 28. CYP8B1
- [This gene plays a role in steroid metabolism and regulation of cholesterol solubility. ( NCI )] (UMLS (NCI) C1413895) CYP8B1 Gene;
Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 Gene =Gene or Genome |
- 10. CYP1A1
- [This gene plays a role in the oxidation of procarcinogens. This process activates these compounds to carcinogens. ( NCI )] (UMLS (NCI) C0919425) CYP1A1 Gene;
Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 Gene =Gene or Genome ;
| - 29. CyPat
- (UMLS (NCI) C0919249) =Steroid; Pharmacologic Substance ;
|
- 11. CYP1A2
- [This gene plays a role in the oxidation/activation of procarcinogens. It is also involved in the metabolism of drugs and other xenobiotics. ( NCI )] (UMLS (NCI) C1332826) CYP1A2 Gene;
Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 Gene =Gene or Genome | - 30. Cypovirus
- [isolated from arthropods; virions occluded within proteinaceous occlusion bodies (polyhedra); 12 virus types have been identified. ( CSP )] (UMLS (CSP) C1148555) =Virus =Reoviridae;
|
- 12. CYP21A2
- [This gene plays a role in steroid metabolism. ( NCI )] (UMLS (NCI) C1413861) CYP21A2 Gene;
Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 Gene =Gene or Genome | - 31. Cypridina luciferin 2 monooxygenase
- [ ] (UMLS (CSP) C0311726) =Amino Acid, Peptide, or Protein; Enzyme
|
- 13. CYP27B1
- [This gene is involved in vitamin D metabolism and calcium homeostasis. ( NCI )] (UMLS (NCI) C1413865) CYP27B1 Gene;
Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 Gene =Gene or Genome | - 32. Cyprinidae
- [any of various freshwater fish of the family Cyprinidae. ( CSP )] (UMLS (CSP) C0010613) =Fish ;
=bony fish;
=Carassius auratus;
Brachydanio rerio;
|
- 14. CYP2A6
- [This gene plays a role in the oxidation of nicotine to its carcinogenic metabolites. ( NCI )] (UMLS (NCI) C1413868) CYP2A6 Gene;
Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 Gene =Gene or Genome | - 33. Cyprinus
- [Genus containing one species (Cyprinus carpio), in the family CYPRINIDAE. ( MSH )] (UMLS (CSP) C0086083) =Fish
|
- 15. CYP2B6
- [This gene is involved in the oxidation of both endogenous substrates and drugs/xenobiotics. ( NCI )] (UMLS (NCI) C1382176) CYP2B6 Gene;
Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 Gene =Gene or Genome | - 34. cyproheptadine
- [serotonin antagonist and histamine H1 blocker used as an antipruritic, appetite stimulant, antiallergic, and to treat the post-gastrectomy dumping syndrome. ( CSP )] (UMLS (CSP) C0010620) =Organic Chemical; Pharmacologic Substance =[AH000] ANTIHISTAMINES;
Dibenzocycloheptenes;
Piperidines;
cycloheptane;
[AH700] ANTIHISTAMINES, PIPERIDINE;
=azatadine;
LORATADINE;
CYPROHEPTADINE HYDROCHLORIDE |
- 16. CYP2C18
- [This gene plays a role in the metabolism of fatty acids, tryptophan, drugs and xenobiotics. ( NCI )] (UMLS (NCI) C1378702) CYP2C18 Gene;
Cytochrome P450, Family 2, Subfamily C, Polypeptide 18 Gene;
=Gene or Genome | - 35. cyproterone
- [A synthetic steroidal anti-androgen with antineoplastic activity. Cyproterone, in its acetate form, binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progesterogenic activity, resulting in a reduction in testicular androgen secretion and total androgen blockade. (NCI04) ( NCI )] (UMLS (CSP) C0010621) =Steroid; Pharmacologic Substance
|
- 17. CYP2C19
- [This gene is involved in the metabolism of drugs and xenobiotics. ( NCI )] (UMLS (NCI) C1332828) CYP2C19 Gene;
Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 Gene =Gene or Genome | - 36. Cyproterone/Leuprolide
- (UMLS (NCI) C1327832) =Therapeutic or Preventive Procedure ;
|
- 18. CYP2C8
- [This gene plays a role in drug metabolism. It is also involved in the oxidation of both endobiotics and xenobiotics. ( NCI )] (UMLS (NCI) C1413873) CYP2C8 Gene;
Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 Gene =Gene or Genome | - 37. Cyproterone/Triptorelin
- (UMLS (NCI) C1327903) =Therapeutic or Preventive Procedure ;
|
- 19. CYP2C9
- [This gene is involved in the oxidation of drugs, xenobiotics, fatty acids and steroids. ( NCI )] (UMLS (NCI) C1332829) CYP2C9 Gene;
Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 Gene =Gene or Genome | |
home
