- 1. DBL
- [This gene is involved in signal transduction. ( NCI )] (UMLS (NCI) C0812211) Diffuse B-Cell Lymphoma Oncogene;
MCF.2 Cell Line Derived Transforming Sequence;
MCF2;
MCF2 Cell Line Derived Transforming Sequence Gene;
MCF2 Gene;
Oncogene DBL;
Oncogene MCF2;
Oncogene, DBL;
Oncogene, MCF-2 =Gene or Genome | - 2. DBL Oncoprotein
- [Human DBL Oncoprotein is product of a mutated variant (Oncogene DBL) of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Activated DBL oncogene is generated by 5-prime recombination with 3 (pter-p21) and by 3-prime recombination with 16 (p13-q22). The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. DBL Oncoprotein disrupts normal cell function. ( NCI )] (UMLS (NCI) C0069500) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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