- 1. (-)-Epothilone B
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called epothilones. Also called EPO906. ( NCI )] (UMLS (NCI) C0297960) =Organic Chemical; Pharmacologic Substance
| - 16. EPO/IL-3
- (UMLS (NCI) C0281349) =Therapeutic or Preventive Procedure
|
- 2. 1,2-Epoxyethane
- [Colorless, odorless, flammable, toxic gaseous cyclic ether with a sweet ether-like smell. Ethylene oxide is used especially in the synthesis of ethylene glycol and as a sterilizing agent for medical supplies and foods, as a fumigant and as an insecticide. Exposure to this substance is highly irritating to the eyes, skin and respiratory tract, induces nausea and vomiting and causes central nervous system depression. Ethylene oxide is mutagenic in humans and chronic exposure is associated with an increased risk of leukemia, stomach cancer, pancreatic cancer and non-Hodgkin's lymphoma. (NCI05) ( NCI )] (UMLS (NCI) C0015087) =Organic Chemical; Hazardous or Poisonous Substance ;
=epoxide;
| - 17. EPO906
- (UMLS (NCI) C1328655) =Organic Chemical; Pharmacologic Substance
|
- 3. 1,2-Epoxyethylbenzene
- [A synthetic, colorless liquid that is very soluble in water. Styrene oxide is used as a chemical intermediate in the production of styrene glycol and its derivatives, cosmetics, surface coatings and other chemicals (agricultural and biological). It is also used as a reactive diluent for epoxy resins and in cross-linked polyesters and polyurethanes. Humans in the general population may be exposed to styrene oxide by contact with contaminated air or water. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0075351) =Organic Chemical
| - 18. Epodyl
- (UMLS (NCI) C0795735) =Organic Chemical; Pharmacologic Substance
|
- 4. 1,2-Epoxypropane
- [A synthetic, highly-flammable, volatile, colorless liquid that is soluble in water and miscible with many organic solvents. Propylene oxide is used primarily as a chemical intermediate in the production of polyethers and propylene glycol. It is also used as a pesticide and a fumigant for the sterilization of packaged foods and plastic medical instruments. Acute inhalation exposure to vapors of this compound can result in respiratory tract irritation, coughing, difficulty in breathing (dyspnea) and buildup of fluid in the lungs (pulmonary edema) that can possibly lead to pneumonia. Inhale high concentrations of the vapors for short time periods may cause headache, motor weakness, incoordination, ataxia and coma. Contact with propylene oxide can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0072229) =Organic Chemical
| - 19. Epoetin Alfa/Filgrastim/Flt3 Ligand/Interleukin-3/Sargramostim
- (UMLS (NCI) C1134599) =Therapeutic or Preventive Procedure
|
- 5. 1,4-Epoxy-1,3-butadiene
- [compounds with a 5-membered ring of four carbons and an oxygen; aromatic heterocycles; the reduced form is tetrahydrofuran. ( CSP )] (UMLS (NCI) C0060850) =Organic Chemical =oxygenous heterocyclic compound;
=benzofuran;
N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine | - 20. Epoetin Alfa/Thalidomide
- (UMLS (NCI) C1327824) =Therapeutic or Preventive Procedure ;
|
- 6. 1-Epoxyethyl-3,4-epoxycyclohexane
- [A synthetic, colorless liquid that is soluble in water. It is used as a reactive diluent for other epoxides and as a monomer in the production of epoxy resins for coatings and adhesives. Occupational exposure of humans to 4-vinyl-1-cyclohexene diepoxide results in skin irritation. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0048737) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 21. Epoetin Beta
- [A recombinant therapeutic agent that is chemically identical to or similar to the endogenous cytokine human erythropoietin (EPO). Produced primarily by cells of the peritubular capillary endothelium of the kidney in response to hypoxia, circulating EPO binds to EPO receptors on the surface of committed erythroid progenitors in the bone marrow resulting in the replication and maturation of these progenitors to functional erythrocytes. (NCI04) ( NCI )] (UMLS (NCI) C0357131) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|
- 7. 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,1
- [A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. However, pimecrolimus mode of action is cell-selective and does not affect Langerhans' cells/dendritic cells and primary fibroblasts. ( NCI )] (UMLS (NCI) C1099414) 33-epi-Chloro-33-desoxyascomycin;
PIMECROLIMUS;
PIMECROLIMUS UNIDENTIFIED;
PIMECROLIMUS PREPARATION;
PIMECROLIMUS UNIDENTIFIED =Organic Chemical; Pharmacologic Substance =[DE900] DERMATOLOGICALS, TOPICAL OTHER;
Unclassified Ingredients =PIMECROLIMUS 1 % | - 22. epogen
- [ ] (UMLS (CSP) C0700704) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone; Immunologic Factor
|
- 8. 2,3-Epoxy-1-propanol
- [Slightly viscous, colorless and odorless liquid cyclic ether. Glycidol is used as a stabilizer for natural oils and vinyl polymers, as an alkylating agent, a sterilant, a demulsifier, a dye-leveling agent and it is also used as an intermediate in the synthesis of glycerol, glycidyl ethers and amines. Exposure to Glycidol irritates the skin, eyes, and mucous membranes and depresses the central nervous system in humans. Glycidol induces mutations in human lymphocytes and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0061587) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
| - 23. EPOPROSTENOL
- [prostaglandin synthesized by the vascular endothelium; potent inhibitor of platelet aggregation and powerful vasodilator. ( CSP )] (UMLS (NCI) C0033567) =Eicosanoid; Pharmacologic Substance; Biologically Active Substance ;
=[HS875] PROSTAGLANDINS;
=Cyclo-Prostin;
|
- 9. 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
- [A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. ( NCI )] (UMLS (NCI) C0030049) =Organic Chemical; Pharmacologic Substance =[CN101] OPIOID ANALGESICS;
codeine =4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride;
Oxycodone Terephthalate;
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride;
Oxycodone Terephthalate;
OXYCODONE 5 MG;
| - 24. EPOR
- [Human erythropoietin receptor protein (508 aa, 55 kDa precursor) is encoded by the human erythropoietin receptor (EPOR) gene. Erythropoietin receptor is a cell surface receptor that binds erythropoietin with high affinity and activates the JAK2 tyrosine kinase pathway. ( NCI )] (UMLS (NCI) C0059570) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 10. 6,7-Epoxytropine Tropate
- [A toluidine derivative and intermediate-acting amino amide with local anesthetic property. Prilocaine stabilizes the neuronal membrane by preferential binding to and inhibiting depolarization of the voltage-gated sodium channel. This results in a decrease in membrane permeability and subsequent inhibition of the ionic sodium influx required for the initiation and conduction of impulses. ( NCI )] (UMLS (NCI) C0033124) =Organic Chemical; Pharmacologic Substance =Anilides;
[CN204] LOCAL ANESTHETICS, INJECTION =2-(Propylamino)-o-propionotoluidide Hydrochloride;
PRILOCAINE 2.5 % | - 25. EPOR
- [This gene plays a pivotal role in erythropoiesis. ( NCI )] (UMLS (NCI) C1333342) EPOR Gene;
Erythropoietin Receptor Gene;
=Gene or Genome ;
|
- 11. EPO
- [A colony-stimulating factor that is made in the laboratory. It increases the production of red blood cells. ( NCI )] (UMLS (NCI) C0357126) =Amino Acid, Peptide, or Protein; Pharmacologic Substance =EPO;
Erythrocyte Colony Stimulating Factor;
[BL400] BLOOD FORMATION PRODUCTS;
=EPO;
Epoetin Alfa 10000 UNT/ML;
Epoetin Alfa 2000 UNT/ML;
Epoetin Alfa 20000 UNT/ML;
Epoetin Alfa 3000 UNT/ML;
Epoetin Alfa 40000 UNT/ML;
Epoetin Alfa 4000 UNT/ML | - 26. Epotein
- (UMLS (HL7) C1547522) =Intellectual Product =Reimbursement Type Code;
|
- 12. EPO
- [This gene is involved in the regulation of red blood cell production and function. ( NCI )] (UMLS (NCI) C1366564) EPO Gene;
Erythropoietin Gene =Gene or Genome | - 27. epothilon
- [A family of drugs obtained from bacteria that interfere with cell division. Some epithilones are being studied as treatments for cancer. ( NCI )] (UMLS (CSP) C1136012) epothilone;
Epothilone Compound;
epothilones =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
thiazole |
- 13. EPO/5-FU/HU/TAX
- (UMLS (NCI) C0393083) =Therapeutic or Preventive Procedure
| - 28. Epothilone A
- [An extract from the myxobacteria Sorangium cellulosum that promotes tubulin polymerization and microtubule stabilization, thereby inhibiting mitosis. Epothilone A appears to be less potent than Epothilone B. (NCI) ( NCI )] (UMLS (NCI) C0297959) =Organic Chemical; Pharmacologic Substance
|
- 14. EPO/G-CSF
- (UMLS (NCI) C0280999) =Therapeutic or Preventive Procedure
| - 29. epoxide
- [3-membered organic ring structure containing oxygen. ( CSP )] (UMLS (CSP) C0014630) =Organic Chemical =Ethers, Cyclic;
oxygenous heterocyclic compound =1,2-Epoxyethane;
oxetane;
sevelamer |
- 15. EPO/GM-CSF/IL-6
- (UMLS (NCI) C0338189) =Therapeutic or Preventive Procedure ;
| - 30. epoxide hydrolase
- [catalyzes the hydrolysis of the ether function of epoxides to glycol important in eicosanoid metabolism, detoxication of mutagens, and other processes. ( CSP )] (UMLS (CSP) C0014628) =Amino Acid, Peptide, or Protein; Enzyme ;
=ether hydrolase;
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