- 1. GDF10
- [This gene plays a role in skeletal morphogenesis and is involved in the regulation of cell growth. ( NCI )] (UMLS (NCI) C1333665) GDF10 Gene;
Growth Differentiation Factor 10 Gene =Gene or Genome ;
| - 6. GDF8
- [Growth Differentiation Factor 8, encoded by the human GDF8 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in the control and maintenance of skeletal muscle mass. It acts specifically as a negative regulator of skeletal muscle growth by signaling through receptor serine/threonine kinases. This protein is synthesized as a preprotein activated by 2 proteolytic cleavages. Removal of the signal sequence is followed by cleavage at a tetrabasic processing site, resulting in a 26-kD amino-terminal propeptide and a 12.5-kD carboxy-terminal peptide, a dimer of which is the biologically active portion of the protein. (From LocusLink, OMIM and NCI) ( NCI )] (UMLS (NCI) C0538238) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 2. GDF15
- [Expressed in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney by human PLAB Gene (BMP/TGF-Beta Family), 308-aa 34-kDa (precursor) Placental TGF-Beta is processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in a disulfide-linked homodimeric secreted mature protein of 224 amino acids. PLAB regulates tissue differentiation and maintenance and reduces the growth of granulocytes and macrophages. Unlike most TGFB superfamily members, in which the amino acid sequence is completely conserved, PLAB shares only 70% amino acid identity with its rodent counterparts. (NCI) ( NCI )] (UMLS (NCI) C0668195) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 7. GDF8
- [This gene plays a role in cell differentiation and the regulation of transcription. It is also involved in the regulation of muscle mass. ( NCI )] (UMLS (NCI) C1333667) GDF8 Gene;
Growth Differentiation Factor 8 Gene =Gene or Genome ;
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- 3. GDF15
- [This gene is involved in the regulation of tissue differentiation. It also plays a role in controlling the growth of granulocytes and macrophages. ( NCI )] (UMLS (NCI) C1335222) GDF15 Gene;
Growth Differentiation Factor 15 Gene =Gene or Genome ;
| - 8. GDF9
- [Growth Differentiation Factor 9, encoded by the human GDF9 gene, is a member of the TGF-beta superfamily. This protein interacts with bone morphogenetic protein-15 and Bone morphogenetic protein receptor type II is a receptor for Growth Differentiation Factor-9. Both GDF9 mRNA and protein are abundantly expressed in oocytes of primary follicles in human ovary, suggesting that the GDF9 transcript is translated at this early stage of folliculogenesis. GDF9 is crucial for normal ovarian folliculogenesis and female fertility. GDF9 regulates human folliculogenesis in a manner specific to the ovary. A dysregulation of GDF9 expression may contribute to aberrant folliculogenesis in PCOS and PCO women. (From OMIM, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0213144) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 4. GDF5
- [Growth Differentiation Factor 5, encoded by the human GDF5 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein is predominantly expressed in long bones during human embryonic development. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0253373) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 9. GDF9
- [This gene plays a role in ovarian folliculogenesis and normal ovulation. ( NCI )] (UMLS (NCI) C1333668) GDF9 Gene;
Growth Differentiation Factor 9 Gene =Gene or Genome ;
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- 5. GDF5
- [This gene is involved in the regulation of axial bone growth during development and plays a role in cellular differentiation. ( NCI )] (UMLS (NCI) C1333666) GDF5 Gene;
Growth Differentiation Factor 5 Gene =Gene or Genome ;
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