- 1. GLI
- [The GLI1 Protein, a Kruppel family protein, is homologous to Drosophila Cubitus interruptus and contains five DNA-binding zinc finger repeats, implicated in transduction of the SHH signal; an endodermal signal that controls hindgut patterning and lung growth. The GLI1 gene is found amplified in a malignant glioma. (from OMIM 165220 and NCI) ( NCI )] (UMLS (NCI) C1449308) GLI Protein;
GLI1;
GLI1 Protein;
Glioma Associated Oncogene Homolog 1 Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 16. Glibenclamide
- [N-4-beta-(2-methoxy-5-chlorobenzamido) -ethylbenzosulfonyl-N'- cyclohexylurea; hypoglycemic used against non-insulin dependent diabetes mellitus; thought to act by increasing insulin receptor expression in target tissues. ( CSP )] (UMLS (NCI) C0017628) =Organic Chemical; Pharmacologic Substance ;
=sulfonylurea;
[HS502] HYPOGLYCEMIC AGENTS, ORAL =GLYBURIDE 1.25 MG;
GLYBURIDE 1.5 MG;
GLYBURIDE 2.5 MG;
GLYBURIDE 3 MG;
GLYBURIDE 5 MG;
GLYBURIDE 6 MG;
GLYBURIDE 4.5 MG |
- 2. GLI Family Gene
- [GLI Family Genes encode DNA-binding GLI Family Proteins containing zinc finger repeats and involved in pattern formation. ( NCI )] (UMLS (NCI) C0919463) =Gene or Genome ;
| - 17. gliding bacteria
- [ ] (UMLS (CSP) C0017633) =Bacterium
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- 3. GLI Family Protein
- [A group of DNA-binding proteins that contain zinc finger repeats and involves pattern formation process. ( NCI )] (UMLS (NCI) C0219804) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 18. GLIMEPIRIDE
- [A sulfonylurea with antihyperglycemic activity. Glimepiride binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, thereby reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-gated calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin, and thereby results in a reduction of the blood glucose level. In addition, this agent increases the sensitivity of peripheral tissues to insulin. ( NCI )] (UMLS (NCI) C0061323) =Organic Chemical; Pharmacologic Substance ;
=sulfonylurea;
[HS502] HYPOGLYCEMIC AGENTS, ORAL =GLIMEPIRIDE 1 MG;
GLIMEPIRIDE 4 MG;
GLIMEPIRIDE 2 MG;
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- 4. gli-3 protein
- [ ] (UMLS (CSP) C1171339) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 19. Glioblastoma with a Sarcomatous Component
- [A type of glioma (cancer of the brain that comes from glial, or supportive, cells). ( NCI )] (UMLS (NCI) C0206726) =Neoplastic Process =glial cell tumor;
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- 5. GLI-Kruppel Family Member HKR3 Gene
- [This gene is involved in transcriptional regulation. ( NCI )] (UMLS (NCI) C0812316) HKR3;
HKR3 Gene =Gene or Genome ;
| - 20. Gliofibroma
- [An astrocytic tumor affecting young people. Morphologically, it is characterized by the presence of collagenous tissue surrounding neoplastic astrocytes. In some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma). ( NCI )] (UMLS (NCI) C1266178) =Neoplastic Process
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- 6. GLI-Kruppel Family Member HKR3 Protein
- [A member of the GLI family of Kruppel-related DNA-binding proteins, the 77 kD HKR3 Protein contains eleven C2H2 zinc fingers, an N-terminus tramtrack-associated box, and an acidic activation domain. (from OMIM 165270 and NCI) ( NCI )] (UMLS (NCI) C0528581) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 21. Glioma of Optic Nerve
- [Abnormal growth of cells that comprise the optic tract. This condition can be seen in association with Neurofibromatosis 1. It is most commonly seen in the pediatric age group. ( NCI )] (UMLS (NCI) C0346326) =Neoplastic Process =astrocytic glioma;
Cranial Nerve II Neoplasms |
- 7. GLI1
- [This gene plays a regulatory role in transcription and embryonic development. ( NCI )] (UMLS (NCI) C0812304) GLI1 Gene;
Glioma-Associated Oncogene Homolog 1 (Zinc Finger Protein) Gene =Gene or Genome | - 22. Glioma of Optic Tract
- [A rare, slow-growing tumor of the eye. ( NCI )] (UMLS (NCI) C0796418) Glioma of the Optic Tract;
Glioma of the Visual Pathway;
Glioma of Visual Pathway;
Optic Tract Glioma;
visual pathway glioma =Neoplastic Process |
- 8. GLI2
- [A Kruppel family protein, GLI2 Protein contains five DNA-binding zinc finger repeats and is implicated in transduction of the SHH signal. GLI2 is a putative oncogene in the development of human BCC. The expression of GLI2 in skin results in activation of multiple SHH target genes. (from OMIM 165230 and NCI) ( NCI )] (UMLS (NCI) C0218975) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 23. Glioma Tumor Suppressor Candidate Region Gene 1 Gene
- [This gene may play a role in the negative regulation of cell growth. ( NCI )] (UMLS (NCI) C1333679) GLTSCR1;
GLTSCR1 Gene;
=Gene or Genome ;
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- 9. GLI2
- [This gene is involved in transcriptional regulation and plays a role in sonic hedgehog signal transduction. ( NCI )] (UMLS (NCI) C0812306) GLI2 Gene;
GLI-Kruppel Family Member GLI2 Gene =Gene or Genome | - 24. Glioma Tumor Suppressor Candidate Region Gene 1 Protein
- [Glioma Tumor Suppressor Candidate Region Gene 1 Protein is encoded by the human GLTSCR1 gene. This protein is expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver, and kidney. Mutation analysis of the transcripts in the gene region in diffuse gliomas with 19q deletions revealed no tumor-specific mutations. However, a marker in GLTSCR1, presumably separated from RAI by several million bases, supplements the most significant marker in RAI in separating cases of basal cell carcinoma (BCC) from controls, which may suggest the presence of an independent, risk-modulating variation in this second gene region. (From OMIM, Swiss-Prot, PubMed 12117772 and NCI) ( NCI )] (UMLS (NCI) C1333680) GLTSCR1;
GLTSCR1 Protein;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 10. GLI3
- [GLI3 Protein is a putative zinc finger DNA-binding transcription factor of the GLI-Kruppel family. GLI3 is homologous to Drosophila Cubitus interruptus (Ci), which regulates patched, gooseberry, and decapentaplegic genes. In response to hedgehog signaling, the full-length cytoplasmic transcriptional activator form of Ci can be cleaved to a nuclear transcription repressor form. Based on GLI3 mutations and phenotypes, GLI3 shows transcriptional activation or repression, and subcellular localization, similar to Ci. Cytoplasmic GLI3 activates PTCH gene expression. PKA-dependent processing of vertebrate GLI3 in the developing limb generates the repressor form, which appears to be antagonized by sonic hedgehog signaling. Mutations of GLI3 may be responsible for Greig Cephalopolysyndactyly Syndrome, Pallister-Hall Syndrome, and Postaxial Polydactyly, suggesting specific roles during development. (from OMIM 165240 and NCI) ( NCI )] (UMLS (NCI) C0082708) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 25. Glioma Tumor Suppressor Candidate Region Gene 2 Gene
- [This gene plays a role in the regulation of protein phosphorylation and turnover. ( NCI )] (UMLS (NCI) C1333682) GLTSCR2;
GLTSCR2 Gene;
=Gene or Genome ;
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- 11. GLI3
- [This gene plays a regulatory role in limb development and is involved in sonic hedgehog signal transduction. ( NCI )] (UMLS (NCI) C0812382) GLI3 Gene;
GLI-Kruppel Family Member GLI3 (Greig Cephalopolysyndactyly Syndrome) Gene =Gene or Genome ;
| - 26. Glioma Tumor Suppressor Candidate Region Gene 2 Protein
- [Expressed in heart, pancreas, placenta, liver, skeletal muscle, kidney, brain, and lung by human GLTSCR2 Gene (GLTSCR2 Family), 478-aa 54-kDa nuclear Glioma Tumor Suppressor Candidate Region Gene 2 Protein interacts with HSV-1 early proteins ICP22 and ICP0. GLTSCR2 function is unknown. (NCI) ( NCI )] (UMLS (NCI) C1333681) GLTSCR2;
GLTSCR2 Protein;
p60 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 12. glia
- [non-neuronal cells of the nervous system; they provide physical support, respond to injury, regulate the ionic and chemical composition of the extracellular milieu, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. ( CSP )] (UMLS (CSP) C0027836) =Cell ;
= ;
Body System, Neurologic =astrocyte;
oligodendrocyte;
Neurilemmal Cell;
gitter cell;
Muller's cell;
| - 27. Gliomatosis of Meninges
- (UMLS (NCI) C1334695) Gliomatosis of the Meninges;
Meningeal Gliomatosis;
Meninges Gliomatosis;
=Neoplastic Process |
- 13. Gliadel Wafer
- (UMLS (NCI) C1171407) =Clinical Drug ;
| - 28. gliosis
- [an excess of neuroglia in damaged areas of the central nervous system. ( CSP )] (UMLS (CSP) C0017639) =Pathologic Function =Central Nervous System Disease;
Pathologic Process |
- 14. glial cell tumor
- [new abnormal neuroglial tissue in any one of its stages of development that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease. ( CSP )] (UMLS (CSP) C0017638) =Neoplastic Process =Neoplasm of Nervous System;
Neoplasm of Neuroepithelial Tissue =astrocytic glioma;
ependymoma;
Medulloblastoma;
astrocytic glioma;
ependymoma;
Medulloblastoma;
Oligodendroglioma;
ganglioglioma;
Glioblastoma with a Sarcomatous Component | - 29. GLIPIZIDE
- [1-cyclohexyl-3-(p-(2-(5-methyl pyrazinecarboxamido) ethyl) phenyl) sulfonylurea; a typical member of the sulfonylurea family of type II (NIDDM) antidiabetic drugs. ( CSP )] (UMLS (NCI) C0017642) =Organic Chemical; Pharmacologic Substance ;
=sulfonylurea;
[HS502] HYPOGLYCEMIC AGENTS, ORAL =GLIPIZIDE 5 MG;
GLIPIZIDE 10 MG;
GLIPIZIDE 2.5 MG |
- 15. Glial Neoplasm Spinal Cord
- [Benign and malignant neoplasms that arise from glial cells of the spinal cord. Subtypes include ependymoma, astrocytoma (including low and high grade forms), medulloblastoma, and oligodendroglioma. ( NCI )] (UMLS (NCI) C0346294) =Neoplastic Process
| - 30. Glisson's Sphincter
- [The muscle fibres around the opening of the common bile duct (ductus choledochus) into the duodenum at the papilla of Vater. ( NCI )] (UMLS (NCI) C0028872) =Body Part, Organ, or Organ Component
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