- 1. HLA A antigen
- [Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts. ( MSH )] (UMLS (CSP) C0019728) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 12. HLA G antigen
- [ ] (UMLS (CSP) C0082920) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 2. HLA antigen
- [Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. ( MSH )] (UMLS (CSP) C0019721) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 13. HLA gene
- [ ] (UMLS (CSP) C0599797) =Gene or Genome ;
|
- 3. HLA B antigen
- [Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes. ( MSH )] (UMLS (CSP) C0019737) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 14. HLA linkage
- [ ] (UMLS (CSP) C0599824) =Natural Phenomenon or Process ;
|
- 4. HLA C antigen
- [Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma). ( MSH )] (UMLS (CSP) C0019751) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 15. HLA Matched
- (UMLS (HL7) C1548978) =Idea or Concept =Blood Product Processing Requirements;
|
- 5. HLA Class I Histocompatibility Antigen, A-2 Alpha Chain
- [Encoded by human HLA-A (A2 allele) Gene (HLA Family), HLA-A2 Antigen is a 365-aa 41-kD class I alpha heavy chain glycoprotein heterodimerized with 11.6-kD beta-2 microglobulin. HLA-A protein organization includes a signal peptide, extracellular alpha1, 2, and 3 domains (90-aa each), a transmembrane region, and a cytoplasmic tail. Polymorphic alpha1 and 2 domains determine peptide binding specificity. Ig-like alpha3 mediates CD8 binding on cytotoxic T-lymphocytes. In the immune response, HLA antigens mediate antigen presentation to TCR. HLA-A2 subtypes are associated with decreased risk of HIV-1 infection and increased frequency of early-onset Alzheimer disease. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0019733) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 16. HLA typing
- [ ] (UMLS (CSP) C0242318) =Laboratory Procedure ;
|
- 6. HLA Class II Histocompatibility Antigen DRB
- [HLA class II DR beta chain proteins (26-28 kD) form heterodimers with alpha (DRA) chains, both anchored in the membrane. Expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages), alpha/beta heterodimers present peptides derived from extracellular proteins. Hundreds of DRB alleles have been described and typing for these polymorphisms is done for transplantation. (NCI) ( NCI )] (UMLS (NCI) C1333901) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 17. HLA-A
- [This gene is involved in immune responses and histocompatibility processes. ( NCI )] (UMLS (NCI) C1333899) HLA-A Gene;
Major Histocompatibility Complex, Class I, A Gene =Gene or Genome ;
|
- 7. HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain
- [Major Histocompatibility Complex, Class II, DP Beta 1 is encoded by the HLA-DPB1 gene. HLA-DPB, an HLA class II beta chain paralogue, plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). HLA-DPB is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the HLA-DPB molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. (from LocusLink) ( NCI )] (UMLS (NCI) C0122007) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 18. HLA-B
- [This gene plays a role in both immune responses and histocompatibility processes. ( NCI )] (UMLS (NCI) C1415561) HLA-B Gene;
Major Histocompatibility Complex, Class I, B Gene =Gene or Genome |
- 8. HLA D antigen
- [Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology. ( MSH )] (UMLS (CSP) C0019754) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 19. HLA-C
- [This gene plays a role in immune responses. ( NCI )] (UMLS (NCI) C1415562) HLA-C Gene;
Major Histocompatibility Complex, Class I, C Gene =Gene or Genome |
- 9. HLA DP antigen
- [A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. ( MSH )] (UMLS (CSP) C0019759) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 20. HLA-DPB1
- [This gene plays a critical regulatory role in antigen presentation and peptide binding specificity. ( NCI )] (UMLS (NCI) C1333900) HLA-DPB1 Gene;
Major Histocompatibility Complex, Class II, DP Beta 1 Gene =Gene or Genome ;
|
- 10. HLA DQ antigen
- [Polymorphic glycoproteins which are expressed primarily in lymphoid cells and function to present antigens for CD4+ T lymphocytes. Certain HLA-DQ protein variants are associated with susceptibility to insulin-dependent diabetes mellitus and several autoimmune diseases. ( NCI )] (UMLS (CSP) C0019761) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 21. HLA-DRB1
- [This gene is involved in immunoregulation and antigen presentation. The gene has several hundred alleles and polymorphism typing is routinely performed for bone marrow and kidney transplantation. ( NCI )] (UMLS (NCI) C1415576) HLA-DRB1 Gene;
Major Histocompatibility Complex, Class II, DR Beta 1 Gene =Gene or Genome |
- 11. HLA DR antigen
- [Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants. ( NCI )] (UMLS (CSP) C0019764) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 22. HLAR agar test
- [Susceptibility, High Level Aminoglycoside Resistance agar test ( HL7V3.0 )] (UMLS (HL7) C1551401) =Laboratory Procedure =ObservationMethod;
|
home
