- 1. (+-)-m-((Ethylamino)-1-hydroxyethyl)phenyl Pivalate
- [A prodrug of etilefrine, an adrenergic agonist with vasoconstrictive activity. Etilefrine pivalate is hydrolyzed to etilefrine, which binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to a decrease in venous pooling and increase in blood pressure. This agent may also stimulate beta-1 adrenergic receptors leading to positive chronotropic and inotropic effects. ( NCI )] (UMLS (NCI) C0059855) =Organic Chemical
| - 51. 5 methoxytryptamine
- [compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups; members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains; they are possibly involved in the etiology of schizophrenia. ( CSP )] (UMLS (CSP) C0000589) =Organic Chemical; Pharmacologic Substance
|
- 2. (+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate Hydrochloride
- [The hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta1-adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation. ( NCI )] (UMLS (NCI) C0700606) =Organic Chemical; Pharmacologic Substance ;
=esmolol;
=ESMOLOL HYDROCHLORIDE 10 MG/ML;
ESMOLOL HYDROCHLORIDE 250 MG/ML;
| - 52. 5 methylcytosine
- [a methylated nucleotide base found in eukaryotic DNA. ( CSP )] (UMLS (CSP) C0049308) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance =cytosine analog;
|
- 3. (+/-)-2-(1-Methylethyl)-4-(1-methylethylidene)-2-cyclohexen-1-ol
- (UMLS (NCI) C0218671) =Organic Chemical; Pharmacologic Substance ;
| - 53. 5,10 methylenetetrahydrofolate
- [A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity. ( NCI )] (UMLS (CSP) C0048858) =Organic Chemical; Pharmacologic Substance; Vitamin =folacin;
|
- 4. (+/-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1)
- [The maleate salt form of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04) ( NCI )] (UMLS (NCI) C0795660) Rosiglitazone Maleate;
ROSIGLITAZONE MALEATE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=Rosiglitazone;
=ROSIGLITAZONE MALEATE 4 MG;
ROSIGLITAZONE MALEATE 8 MG;
ROSIGLITAZONE MALEATE 2 MG;
ROSIGLITAZONE MALEATE 1 MG;
| - 54. 5,10-Methylenetetrahydrofolate Reductase (NADPH) Gene
- [This gene is involved in folate metabolism and methionine biosynthesis. ( NCI )] (UMLS (NCI) C0919427) MTHFR;
MTHFR Gene =Gene or Genome ;
|
- 5. (1-Methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride
- [The hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. At the injection site, mepivacaine hydrochloride acts by binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodium influx. This leads to a blockage of nerve impulse conduction and results in a loss of sensation. ( NCI )] (UMLS (NCI) C0700542) =Organic Chemical; Pharmacologic Substance =MEPIVACAINE;
=MEPIVACAINE HYDROCHLORIDE 3 %;
MEPIVACAINE HYDROCHLORIDE 1 %;
MEPIVACAINE HYDROCHLORIDE 1.5 %;
MEPIVACAINE HYDROCHLORIDE 2 %;
| - 55. 5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
- [substituted benzimidazole used as a gastric acid secretion inhibitor. ( CSP )] (UMLS (NCI) C0028978) =Organic Chemical; Pharmacologic Substance ;
=[GA300] ANTIULCER AGENTS;
benzimidazole;
gastric juice inhibitor;
[GA303] H.PYLORI AGENTS;
[GA900] GASTRIC MEDICATIONS, OTHER;
=LANSOPRAZOLE;
OMEPRAZOLE 10 MG;
OMEPRAZOLE 20 MG;
OMEPRAZOLE 40 MG;
|
- 6. (2) m-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 2-Ester with 2,6-Dihydroxynicotinonitrile Benzoate (Ester)
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0053902) =Organic Chemical; Pharmacologic Substance ;
| - 56. 5-Methoxy-N-acetyltryptamine
- [5-methoxy-N-acetyltryptamine, a pineal hormone involved in modulation of skin pigmentation, gonad development, and circadian rhythms. ( CSP )] (UMLS (NCI) C0025219) =Pharmacologic Substance; Neuroreactive Substance or Biogenic Amine; Hormone =neurohormone;
Unclassified Ingredients;
Unclassified Ingredient Preparations;
=MELATONIN CAP/TAB |
- 7. 1,1'-[(methylethanediylidene)dinitrilo)diguanidine
- [A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C0026251) =Organic Chemical; Pharmacologic Substance ;
=hydrazone;
| - 57. 5-methyltetrahydrofolate:NADP oxidoreductase
- [A flavoprotein (FAD). [EC 1.5.1.20 created 1978 as EC 1.1.1.171, transferred 1984 to EC 1.5.1.20] (from IUBMB). ( NCI )] (UMLS (NCI) C0066357) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 8. 1,2-(methylenedioxy)benzene
- [formula is C7H6O2; synonyms include: (methylenedioxy)benzene; o-methylenedioxybenzene; benzodioxole; 1,2-(methylenedioxy)benzene; 1,3-dioxaindan; 1,3-dioxindan; 3,4-methylenedioxybenzene. ( CSP )] (UMLS (CSP) C0043896) =Organic Chemical =oxygenous heterocyclic compound;
| - 58. 6-(methylmercapto)purine ribonucleoside
- [A purine derivative with antineoplastic and anti-angiogenic properties. 6-methylmercaptopurine riboside (6-MMPR) inhibits amidophosphoribosyltransferase, the first committed step in de novo purine synthesis, and inhibits fibroblast growth factor-2 (FGF2)-induced cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C0025828) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 9. 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
- [noncardioselective beta adrenergic antagonist; used in treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hyperthyroidism, migraine; pheochromocytoma, etc. ( CSP )] (UMLS (NCI) C0033497) =Organic Chemical; Pharmacologic Substance ;
=[CV300] ANTIARRHYTHMICS;
Propanolamines;
beta antiadrenergic agent;
naphthylamine;
coronary vasodilator;
[CV100] BETA-BLOCKERS/RELATED =2-Propanol-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy) Hydrochloride;
PROPRANOLOL 10 MG;
PROPRANOLOL 40 MG;
| - 59. 6-Methoxy-7,4'-dihydroxyisoflavone
- (UMLS (NCI) C0253391) =Organic Chemical ;
|
- 10. 1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene Hydrochloride
- [The hydrochloride salt form of maprotiline, a tetracyclic antidepressant closely related to the tricyclic antidepressants with adrenergic activity and sedative properties. Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors. ( NCI )] (UMLS (NCI) C0700455) =Organic Chemical; Pharmacologic Substance =MAPROTILINE;
=MAPROTILINE HYDROCHLORIDE 25 MG;
MAPROTILINE HYDROCHLORIDE 50 MG;
MAPROTILINE HYDROCHLORIDE 75 MG | - 60. 6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid
- [6-methoxy-alpha-methyl-2-naphthaleneacetic acid; nonsteroidal antiinflammatory drug (NSAID); acts by inhibiting cyclooxygenase and thus prostaglandin synthesis; tocolytic oxytocin antagonist. ( CSP )] (UMLS (NCI) C0027396) =Organic Chemical; Pharmacologic Substance =NSAIDs;
[CN850] ANTIPYRETICS;
Naphthaleneacetic Acids;
naphthalene;
antiarthritic agent;
oxidoreductase inhibitor;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
[CN104] NONSTEROIDAL ANTI-INFLAMMATORY ANALGESICS =NAPROXEN SODIUM;
NAPROXEN 250 MG;
NAPROXEN 375 MG;
NAPROXEN 500 MG;
NAPROXEN 125 MG/5ML;
|
- 11. 1-Methoxy-2-nitrobenzene
- [A synthetic, colorless or slightly yellow liquid that is insoluble in water and soluble in most organic solvents. It is used primarily as a precursor to o-anisidine, which is used extensively in the synthesis of azo dyes. 2-Nitroanisole is also used as an intermediate for the preparation of pharmaceuticals products. The primary routes of potential human exposure to 2-nitroanisole are dermal contact, ingestion and inhalation. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0046435) =Organic Chemical; Hazardous or Poisonous Substance
| - 61. 6-Methyleneandrosta-1,4-diene-3,17-dione
- [An anticancer drug used to decrease estrogen production and suppress the growth of estrogen-dependent tumors. ( NCI )] (UMLS (NCI) C0851344) Exemestane;
EXEMESTANE PREPARATION =Steroid; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
FCE 24304 =EXEMESTANE 25 MG |
- 12. 1-Methyl-1-nitrosourea
- [methylated nitrosourea compound with alkylating, carcinogenic, and mutagenic properties. ( CSP )] (UMLS (NCI) C0025803) =Organic Chemical; Hazardous or Poisonous Substance ;
=Cancer Causing Agents;
nitrosourea | - 62. 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine
- [immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen. ( CSP )] (UMLS (NCI) C0004482) =Organic Chemical; Pharmacologic Substance
|
- 13. 1-Methyl-3-nitro-1-nitrosoguanidine
- [radiomimetic, DNA strand breaking agent used as a "direct acting" experimental carcinogen. ( CSP )] (UMLS (NCI) C0025800) =Organic Chemical; Hazardous or Poisonous Substance ;
=antimetabolite;
Cancer Causing Agents;
nitrosoguanidine;
| - 63. 7-(1-Methylethoxy)-3-phenyl-4H-1-benzopyran-4-one
- (UMLS (NCI) C0123903) =Organic Chemical; Pharmacologic Substance ;
|
- 14. 1-methylethyl-2-chloro-5-[[5,6-dihydro-2-methyl- 1, 4-oxathiin-3-yl-carbonyl]-amino]benzoate
- (UMLS (NCI) C0220323) =Organic Chemical; Pharmacologic Substance
| - 64. 8-Methoxypsoralen
- [A drug used in ultraviolet light therapy. ( NCI )] (UMLS (NCI) C0025684) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =Psoralens;
[DE801] ANTIPSORIATICS, SYSTEMIC;
[DE900] DERMATOLOGICALS, TOPICAL OTHER;
=METHOXSALEN 10 MG;
METHOXSALEN 1 %;
|
- 15. 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine
- [A phenothiazine derivative and a dopamine antagonist with antipsychotic and antiemetic activities. Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium. ( NCI )] (UMLS (NCI) C0040979) =Organic Chemical; Pharmacologic Substance ;
=Phenothiazine;
[CN701] PHENOTHIAZINES/RELATED, ANTIPSYCHOTICS =10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride | - 65. 8-methyl-6-piperidino-s-triazolo (4,3-b)Pyridazine
- (UMLS (NCI) C0078807) =Organic Chemical; Pharmacologic Substance
|
- 16. 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride
- [A hydrochloride salt form of trifluoperazine, a phenothiazine derivative and a dopamine antagonist with antipsychotic and antiemetic activities. Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium. ( NCI )] (UMLS (NCI) C0304381) =Organic Chemical; Pharmacologic Substance =10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine;
=TRIFLUOPERAZINE HYDROCHLORIDE 2 MG/ML;
TRIFLUOPERAZINE HYDROCHLORIDE 1 MG;
TRIFLUOPERAZINE HYDROCHLORIDE 2 MG;
TRIFLUOPERAZINE HYDROCHLORIDE 5 MG;
TRIFLUOPERAZINE HYDROCHLORIDE 10 MG/ML;
TRIFLUOPERAZINE HYDROCHLORIDE 10 MG;
| - 66. 9-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one
- (UMLS (NCI) C0063435) =Organic Chemical; Pharmacologic Substance
|
- 17. 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine Hydrochloride
- (UMLS (NCI) C0304371) =Organic Chemical; Pharmacologic Substance =METHDILAZINE;
| - 67. meta analysis
- [quantitative method of combining results of independent studies (usually drawn from published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in areas of research and medicine. ( CSP )] (UMLS (CSP) C0920317) Meta-Analysis =Research Activity =Biometrics;
|
- 18. 2,2'-Methylenebis(3,4,6-trichlorophenol)
- [A chlorinated bisphenol antiseptic agent with bacteriostatic activity. Hexachlorophene is used topically in soaps, creams and dermatological preparations and is active against gram-positive organisms, but much less effective against gram-negative organisms. (NCI05) ( NCI )] (UMLS (NCI) C0019435) =Organic Chemical; Pharmacologic Substance ;
=Chlorophenols;
[DE400] SOAPS/SHAMPOOS/SOAP-FREE CLEANSERS =HEXACHLOROPHENE 450 MG;
HEXACHLOROPHENE 480 MG;
HEXACHLOROPHENE 3 %;
HEXACHLOROPHENE 0.25 %;
HEXACHLOROPHENE 1 %;
HEXACHLOROPHENE 5 MG;
| - 68. metabolic
- [Having to do with metabolism. ( NCI )] (UMLS (NCI) C0311400) =Functional Concept
|
- 19. 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, Hydrochloride, (2R,6R,11R)-rel-
- [The hydrochloride salt form of pentazocine, a benzomorphan narcotic agonist-antagonist. Pentazocine hydrochloride binds to and activates kappa- and sigma-opioid receptors, resulting in sedation and analgesia. In addition, this agent antagonizes the mu-receptor. Pentazocine hydrochloride partially reverses opiate-induced cardiovascular, respiratory, and behavioral depression. ( NCI )] (UMLS (NCI) C0355587) =Organic Chemical; Pharmacologic Substance =PENTAZOCINE;
=PENTAZOCINE HYDROCHLORIDE 50 MG;
PENTAZOCINE HYDROCHLORIDE 12.5 MG;
PENTAZOCINE HYDROCHLORIDE 25 MG | - 69. METABOLIC CARDIOMYOPATHY
- [ ] (UMLS (ICD9CM) C0340422) =Disease or Syndrome ;
|
- 20. 2-(1-Methylethyl)-4-pentenamide
- [An allylic compound that acts as a suicide inactivator of CYTOCHROME P450 by covalently binding to its heme moiety or surrounding protein. ( MSH )] (UMLS (NCI) C0002160) =Organic Chemical
| - 70. Metabolic Disease
- [condition in which there is a deviation from or caused by an abnormal metabolic process; can be congenital due to inherited enzyme abnormality (INBORN METABOLISM DISORDER) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. ( CSP )] (UMLS (NCI) C0025517) =Disease or Syndrome =Disease;
Nutritional and Metabolic Diseases =acidosis;
alkalosis;
amyloid disease;
Bone Diseases, Metabolic;
Diabete mellito;
histiocytosis X;
hyperbilirubinemia;
Congenital Metabolic Disorder;
DIS PHOSPHORUS METABOL;
DIS PORPHYRIN METABOLISM;
Alteracoes do metabolismo lipidico;
steroid metabolism disorder;
FLUID OVERLOAD;
hypovolemia;
acquired aminoacid metabolism disorder;
metal metabolism disorder;
protein metabolism disorder;
hyperuricemia;
mitochondrial disease;
achlorhydria;
Acid-Base Imbalance;
Brain Diseases, Metabolic;
calcium metabolism disorder;
diabetes insipidus;
Diabete mellito;
DIS IRON METABOLISM;
glycosuria;
hyperbilirubinemia;
Blood Glucose, High;
hyperinsulinemia;
hyperlipemia;
hyperprolactinemia;
HYPERVITAMINOSIS A;
Blood Glucose, Low;
gastrointestinal absorption disorder;
Congenital Metabolic Disorder;
DIS PHOSPHORUS METABOL;
Protein-Losing Enteropathies;
Wasting Syndrome;
Water-Electrolyte Imbalance;
xanthelasmatosis;
enzyme deficiency;
Hyperammonemia;
hyperuricemia |
- 21. 2-(Methacryloyloxy)ethanol
- [A hydroxyester compound and a resin monomer used in desensitizing dentin. By applying 2-hydroxyethyl methacrylate locally to sensitive teeth, sensitive areas in the teeth get sealed and block the dentinal tubules at the dentin surface from stimuli that cause pain. This prevents excitation of the tooth nerve and relieves pain caused by tooth hypersensitivity. ( NCI )] (UMLS (NCI) C0063127) =Organic Chemical; Biomedical or Dental Material ;
| - 71. Metabolic disorders following abortion or ectopic and molar pregnancies
- [ ] (UMLS (ICD9CM) C0495172) =Disease or Syndrome
|
- 22. 2-(Methoxycarbonyl)propene
- [A methyl ester of methacrylic acid. Methyl methacrylate is a reactive resin, and the polymerized form is used as cement in dentistry, orthopaedic surgery and ophthalmology. The monomer form of this agent has relaxation effect on smooth muscle systemically, which might be a result of nitric oxide-mediated response. ( NCI )] (UMLS (NCI) C0066409) =Organic Chemical; Biomedical or Dental Material ;
=Methylmethacrylates;
[XX000] MISCELLANEOUS AGENTS;
Inactive Ingredient Preparations;
=METHYL METHACRYLATE 100 % | - 72. metabolic equivalent
- [3.5 mL/min/kg ( HL7V3.0 )] (UMLS (HL7) C1552986) =Quantitative Concept =UnitOfMeasureAtomInsens;
UnitOfMeasureAtomSens |
- 23. 2-Methoxy-5-Methylaniline
- [A white, crystalline aromatic amine that is soluble in organic solvents and emits toxic fumes of nitrogen oxides when heated to decomposition. p-Cresidine is exclusively used as a chemical intermediate in the manufacture of dyes. p-Cresidine is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0056481) =Organic Chemical; Pharmacologic Substance ;
| - 73. Metabolic Pathway
- [An elaboration of the known steps and interactions for the metabolism of a compound. ( NCI )] (UMLS (NCI) C1291081) Metabolic Pathways;
Metabolism =Functional Concept ;
|
- 24. 2-Methyl-1,3-butadiene
- [An unsaturated pentahydrocarbon, Isoprene is found in certain plants or obtained by distillation of caoutchouc or gutta-percha. In plants, it is elementary in the formation of isoprenoids, fat-soluble vitamins, carotenoids and related pigments. Isoprenes contribute to flavors and fragrances of essential oils and other plant-derived substances. (NCI04) ( NCI )] (UMLS (NCI) C0064044) =Organic Chemical
| - 74. metabolic respiration
- [ ] (UMLS (CSP) C0598105) =Cell Function
|
- 25. 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
- [A sedative, hypnotic agent that was used for insomnia, but was taken off of the market, in the U.S., in 1983 due to its high risk of abuse.(NCI) ( NCI )] (UMLS (NCI) C0025627) =Organic Chemical; Pharmacologic Substance ;
| - 75. metabolic syndrome
- [a multifaceted syndrome characterized by clustering of insulin resistance and hyperinsulinemia, associated with dyslipidemia, essential hypertension, abdominal obesity, glucose intolerance or noninsulin dependent diabetes mellitus, and an increased risk of cardiovascular events. ( CSP )] (UMLS (CSP) C0948265) =Disease or Syndrome =hyperinsulinemia;
syndrome;
insulin sensitivity/resistance;
|
- 26. 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
- [A sulfonamide derivative and a member of the quinazoline family, chemically related to thiazides, with diuretic, antihypertensive and antiurolithic properties. By blocking Na/Cl transporter, metolazone inhibits electrolyte reabsorption in the distal convoluted tubule and proximal tubule in the kidney. This prevents salt and fluid retention, leading to decreased plasma volume and reduce peripheral resistance of blood vessels, thereby reversal of hypertension. ( NCI )] (UMLS (NCI) C0025854) =Organic Chemical; Pharmacologic Substance ;
=[CV701] THIAZIDES/RELATED DIURETICS;
quinazoline;
sulfonamide;
=METOLAZONE 0.5 MG;
METOLAZONE 10 MG;
METOLAZONE 2.5 MG;
METOLAZONE 5 MG;
| - 76. Metabolism and Nutrition Disorder Class
- [A class of disorders that encompasses conditions occurring as a result of metabolic dysfunction or deviation from the normal nutritional requirements. (NCI) ( NCI )] (UMLS (NCI) C0851358) METABOLISM AND NUTRITION DISORDERS;
=Disease or Syndrome |
- 27. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
- [A synthetic derivative of thienobenzodiazepine with antipsychotic properties. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through a combination of dopamine and serotonin type 2 antagonism. ( NCI )] (UMLS (NCI) C0171023) =Organic Chemical; Pharmacologic Substance ;
=Pirenzepine;
[CN709] ANTIPSYCHOTICS, OTHER =olanzapine 10 MG Disintegrating Tablet;
OLANZAPINE 10 MG;
OLANZAPINE 2.5 MG;
OLANZAPINE 7.5 MG;
OLANZAPINE 5 MG;
OLANZAPINE 15 MG;
OLANZAPINE 20 MG | - 77. metabolism disorder chemotherapy
- [application of the beneficial effects of drugs to control or cure diseases or abnormal states of metabolism. ( CSP )] (UMLS (CSP) C0596911) =Therapeutic or Preventive Procedure ;
=chemotherapy;
|
- 28. 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- [An anticancer drug that belongs to the family of drugs called antiandrogens. ( NCI )] (UMLS (NCI) C0016384) =Organic Chemical; Pharmacologic Substance ;
=Anilides;
[AN000] ANTINEOPLASTICS =FLUTAMIDE 125 MG;
| - 78. metabolism disorder diagnosis
- [determination of the presence of a diseases caused by an abnormal metabolic process based on symptoms, medical history, risk factors, and clinical tests. ( CSP )] (UMLS (CSP) C0596912) =Diagnostic Procedure ;
=Diagnosed;
=inborn metabolism disorder diagnosis |
- 29. 2-methylacyl-CoA Racemase
- [Human alpha-methylacyl-CoA racemase protein (382 aa, ~42.4 kDa) is encoded by the AMCAR gene (AMACR). This protein is an enzyme that is involved in the beta-oxidation of branched-chain fatty acids. Overexpression of this protein has been found in several carcinomas, thus it is considered an important biomarker in the pathogenesis of breast, prostate, and colon cancers. ( NCI )] (UMLS (NCI) C0666209) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 79. METABOLISM DISORDER NEC
- [ ] (UMLS (ICD9CM) C0494362) =Disease or Syndrome
|
- 30. 2-Methylallyl Chloride
- [A synthetic, flammable, volatile, colorless to straw-colored liquid that is insoluble in water and soluble in chloroform, acetone, alcohol, ether and benzene. It is used primarily as a chemical intermediate in the production of carbofuran, a carbamate insecticide; used in the production of herbicides, plastics, pharmaceuticals, and other organic as well as an additive in textiles and perfumes. When heated to decomposition, it emits toxic fumes of hydrochloric acid and other chlorinated compounds. Contact exposure of this substance causes irritation of the eyes and skin. Inhalation can lead to irritation of the respiratory tract and depression of the central nervous system. Breathing at high levels of 3-chloro-2-methylpropene vapors may induce coughing, gasping, breathing difficulties and extreme respiratory distress, even coma. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0047290) =Organic Chemical; Hazardous or Poisonous Substance
| - 80. Metabolism, Purines/Pyrimidines/Nucleotides/Nucleic Acids
- [sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of nucleotides; the buildup and breakdown of nucleotides for utilization by the organism. ( CSP )] (UMLS (NCI) C0597108) =Molecular Function ;
=Intermediary Metabolism;
|
- 31. 3 methoxy 4 hydroxyphenylethyleneglycol
- [metabolite of epinephrine and norepinephrine found in blood, brain, CSF, and urine, where it is used as a measure of catecholamine turnover. ( CSP )] (UMLS (CSP) C0025691) =Organic Chemical; Biologically Active Substance ;
=alcohol;
| - 81. Metabolite
- [Any substance involved in metabolism, either as a product of metabolism or as necessary for metabolism. ( NCI )] (UMLS (NCI) C0870883) =Biologically Active Substance ;
|
- 32. 3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one)
- [An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. ( MSH )] (UMLS (NCI) C0005640) =Organic Chemical; Pharmacologic Substance
| - 82. METACAR/CAR DIVISION NEC
- [ ] (UMLS (ICD9CM) C0177343) =Therapeutic or Preventive Procedure
|
- 33. 3,4 methylenedioxyamphetamine
- [abused, controlled, serotonergic hallucinogen of the "designer drug" class; probably the active metabolite of MDMA ("ecstasy"). ( CSP )] (UMLS (CSP) C0000379) =Organic Chemical; Pharmacologic Substance ;
| - 83. METACAR/CAR WEDG OSTEOTO
- [ ] (UMLS (ICD9CM) C0187205) =Therapeutic or Preventive Procedure
|
- 34. 3,4 methylenedioxymethamphetamine
- [synthetic adrenergic agonist resembling both amphetamine (a stimulant) and mescaline (a hallucinogen); "designer drug" once touted as potentially psychotherapeutic, but now a controlled substance considered a drug of abuse. ( CSP )] (UMLS (CSP) C0115471) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =Amfetamine;
hallucinogen | - 84. METACARP/CARP INJ OP NOS
- [ ] (UMLS (ICD9CM) C0187066) =Therapeutic or Preventive Procedure
|
- 35. 3-(Methylseleno)-l-alanine
- (UMLS (NCI) C0074299) =Organic Chemical; Pharmacologic Substance ;
| - 85. METACARP/CARP SEQUESTREC
- [ ] (UMLS (ICD9CM) C0177324) =Therapeutic or Preventive Procedure
|
- 36. 3-methyl TTNEB
- [An anticancer drug used to decrease the growth of some types of cancer cells. Also called bexarotene. ( NCI )] (UMLS (NCI) C0765273) 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid;
Bexarotene;
BEXAROTENE PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
Retinoic Acid Agent =BEXAROTENE 75 MG;
BEXAROTENE 1 % | - 86. Metacarpal
- [The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally. ( MSH )] (UMLS (HL7) C0025526) =Body Part, Organ, or Organ Component =Body Part;
|
- 37. 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide
- [peripheral vasodilator that reduces blood pressure; diazoxide also has antidiuretic and hypoglycemic effects. ( CSP )] (UMLS (NCI) C0012022) =Organic Chemical; Pharmacologic Substance =antihypertensive agent;
benzothiadiazine;
[CV490] ANTIHYPERTENSIVES, OTHER;
thiazide;
[HS503] ANTIHYPOGLYCEMICS;
=DIAZOXIDE 15 MG/ML;
DIAZOXIDE 50 MG/ML;
DIAZOXIDE 50 MG;
| - 87. METACARPOCARPAL FUSION
- [ ] (UMLS (ICD9CM) C0187394) =Therapeutic or Preventive Procedure
|
- 38. 3-Methylglutaconyl-CoA Hydratase
- [AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. (LocusLink) ( NCI )] (UMLS (NCI) C0066377) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 88. METACARPOPHALANGEAL FUS
- [ ] (UMLS (ICD9CM) C0187606) =Therapeutic or Preventive Procedure
|
- 39. 4'-Methylgenistein
- [An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer. ( NCI )] (UMLS (NCI) C0053622) =Organic Chemical; Pharmacologic Substance ;
| - 89. Metacarpophalangeal Joint
- [The articulation between a metacarpal bone and a phalanx. ( MSH )] (UMLS (NCI) C0025525) =Body Space or Junction
|
- 40. 4,4'-Methylenebisbenzenamine
- [A yellowish to brownish colored crystalline solid aromatic amine with a faint amine-like odor that is unstable in the presence of light or air and emits toxic fumes of aniline and nitrogen oxides when heated to decomposition. 4,4'-Methylenedianiline is primarily used in industry as a chemical intermediate in the production of 4,4-methylenedianiline diisocyanates and polyisocyanates, but is also used as a cross-linking agent for the determination of tungsten and sulfates, and as a corrosion inhibitor. Exposure to this substance irritates the skin and eyes and causes liver damage. 4,4'-Methylenedianiline is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0047805) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 90. Metachronous Malignant Neoplasm
- [A malignant tumor that arises at a site separate from another, primary malignant tumor in the same anatomic system. It is not clear if metachronous malignant neoplasms represent new primary tumors or metastatic disease. Examples include metachronous osteosarcoma of the bones that develops in patients with known primary bone osteosarcoma, and metachronous Wilms' tumor that affects the opposite kidney in patients with a history of Wilms' tumor. ( NCI )] (UMLS (NCI) C1334703) =Neoplastic Process
|
- 41. 4-(1-Methylethenyl)-1-cyclohexene-1-carboxylic Acid
- (UMLS (NCI) C0211503) =Organic Chemical
| - 91. Metachronous Osteosarcoma
- [A bone osteosarcoma that has metastasized to skeletal or extraskeletal sites. ( NCI )] (UMLS (NCI) C1334704) Metachronous Osteosarcoma of the Bone;
=Neoplastic Process |
- 42. 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
- [A drug that reduces pain. Celecoxib belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is being studied for cancer prevention. ( NCI )] (UMLS (NCI) C0538927) =Organic Chemical; Pharmacologic Substance =sulfonamide;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =CELECOXIB 100 MG;
CELECOXIB 200 MG;
CELECOXIB 400 MG | - 92. Metachronous Wilms Tumor
- [Wilms tumor arising in the remaining kidney following treatment of the original Wilms tumor. ( NCI )] (UMLS (NCI) C1334705) Metachronous Wilms' Tumor;
Metachronous Wilms Tumor of the Kidney =Neoplastic Process |
- 43. 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
- [A substance that is being studied as a treatment for pain and other side effects of cancer therapy. It belongs to the family of drugs called COX-2 inhibitors. ( NCI )] (UMLS (NCI) C0913246) Valdecoxib;
VALDECOXIB PREPARATION;
VALDECOXIB UNIDENTIFIED;
=Organic Chemical; Pharmacologic Substance ;
=[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
Unclassified Ingredients =VALDECOXIB 10 MG;
VALDECOXIB 20 MG | - 93. metacyclogenesis
- [ ] (UMLS (CSP) C1171356) =Natural Phenomenon or Process ;
|
- 44. 4-(6-Methoxy-2-naphthalenyl)-2-butanone
- [A naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activity. Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of nabumetone. The formation of thromboxane A2, by thromboxane synthase, is also decreased and results in an inhibition of platelet aggregation. ( NCI )] (UMLS (NCI) C0068334) =Organic Chemical; Pharmacologic Substance ;
=Butanones;
[CN104] NONSTEROIDAL ANTI-INFLAMMATORY ANALGESICS =NABUMETONE 750 MG;
NABUMETONE 500 MG;
| - 94. metagenesis
- [ ] (UMLS (CSP) C0598780) =Organism Function ;
|
- 45. 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone
- [A yellowish crystalline solid nitrosamine that naturally occurs in tobacco products by oxidation and nitrosation of nicotine during the making and smoking of tobacco. 4-Methylnitrosamino-1,3-pyridyl-1-butanone is only used as a research chemical to induce tumorigenesis. This substance is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0047964) =Organic Chemical; Pharmacologic Substance ;
| - 95. METAGONIMIASIS
- (UMLS (ICD9CM) C0025530) =Disease or Syndrome
|
- 46. 4-Methylphenol
- (UMLS (NCI) C0048212) =Organic Chemical ;
| - 96. metal
- [element marked by luster, malleability, ductility, and conductivity of electricity and heat and which will ionized positively in solution. ( CSP )] (UMLS (CSP) C0025552) =Inorganic Chemical =Element;
Inorganic Chemical =Al element;
alkali metal;
alkaline earth metal;
heavy metal;
alkali metal;
alkaline earth metal;
Metals, Rare Earth;
heavy metal;
Metals, Light;
|
- 47. 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
- [An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that contain the Philadelphia chromosome. Imatinib also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF)/c-kit; the SCF/c-kit receptor tyrosine kinase is activated in gastrointestinal stromal tumor (GIST). This agent inhibits proliferation and induces apoptosis in cells that overexpress these oncoproteins. ( NCI )] (UMLS (NCI) C0935989) Imatinib;
IMATINIB PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
Unclassified Ingredients =4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Monomethanesulfonate;
IMATINIB 100 MG | - 97. metal complex
- [ ] (UMLS (CSP) C0596913) =Chemical Viewed Structurally ;
=chemical aggregate;
=Organometallic Compound |
- 48. 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Monomethanesulfonate
- [A drug that is being studied for its ability to inhibit the growth of certain cancers. It interferes with a portion of the protein produced by the bcr/abl oncogene. Also called Gleevec and STI571. ( NCI )] (UMLS (NCI) C0939537) Imatinib Mesylate;
IMATINIB MESYLATE PREPARATION =Organic Chemical; Pharmacologic Substance =4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide;
Unclassified Ingredients =IMATINIB MESYLATE 100 MG;
IMATINIB MESYLATE 400 MG | - 98. metal dental material
- [metal material used in temporary or permanent dental implants, biomaterials, prosthetic devices, etc. ( CSP )] (UMLS (CSP) C0596914) =Biomedical or Dental Material ;
=Dental Material;
=dental amalgam |
- 49. 4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
- [A substance used for pain relief that is also being studied for its ability to prevent cancer and to block the growth of new blood vessels to solid tumors. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs. ( NCI )] (UMLS (NCI) C0762662) Rofecoxib;
ROFECOXIB PREPARATION;
=Organic Chemical; Pharmacologic Substance =LACTONE;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =ROFECOXIB 50 MG;
ROFECOXIB 12.5 MG/5ML;
ROFECOXIB 25 MG/5ML;
ROFECOXIB 25 MG;
ROFECOXIB 12.5 MG;
| - 99. Metal Free
- (UMLS (HL7) C1550120) =Intellectual Product =Special Handling Code;
◊ [Container is free of heavy metals, including lead. ( HL7V3.0 )] (UMLS (HL7) C1553200) Idea or Concept EntityHandling; |
- 50. 5 methoxy N,N dimethyltryptamine
- [major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. ( CSP )] (UMLS (CSP) C0000588) =Organic Chemical; Biologically Active Substance ;
| - 100. metal fume fever
- [ ] (UMLS (CSP) C0238276) =Injury or Poisoning
|
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