- 1. ORC group
- (UMLS (HL7) C1550164) =Idea or Concept =Segment group;
| - 11. ORC6
- [Expressed throughout the cell cycle, human ORC6L Gene (ORC6 Family) encodes nuclear 252-aa 28-kDa Origin Recognition Complex Subunit 6, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. While ORC6L and ORC1L loosely associate with the core ORC complex of ORC2L, -3L, -4L and -5L, ORC6 also interacts with other proteins, including a 65-kDa hyperphosphoprotein (G1) dephosphorylated in mitosis. Essential in coordinating chromosome replication/segregation with cytokinesis, ORC6L also has a role in transcriptional silencing. (NCI) ( NCI )] (UMLS (NCI) C1335138) ORC6L;
Origin Recognition Complex Subunit 6;
Origin Recognition Complex Subunit 6 Homolog-Like;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2. ORC Subunit Gene
- [DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to the ARS Consensus Sequence (ACS) of Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication and are essential for viability. ( NCI )] (UMLS (NCI) C1335089) =Gene or Genome
| - 12. ORC6L
- [This gene is involved in DNA binding, initiation of DNA replication and transcriptional silencing. ( NCI )] (UMLS (NCI) C1335088) ORC6L Gene;
Origin Recognition Complex, Subunit 6 Homolog-Like (Yeast) Gene;
=Gene or Genome |
- 3. ORC1L
- [This gene plays a role in DNA binding, initiation of DNA replication and transcriptional silencing. It is also involved in ATP hydrolysis and the maintenance of cell viability. ( NCI )] (UMLS (NCI) C1335083) ORC1L Gene;
Origin Recognition Complex, Subunit 1-Like (Yeast) Gene;
=Gene or Genome ;
| - 13. Orcein stain
- [Stain, Orcein ( HL7V3.0 )] (UMLS (HL7) C1294001) =Laboratory Procedure =ObservationMethod;
|
- 4. ORC2
- [Expression (testes highest) not regulated during cell proliferation, human ORC2L Gene (ORC2 Family) encodes 577-aa 66-kDa nuclear Origin Recognition Complex Subunit 2, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. ORC2L forms a core ORC complex with ORC1L, -3L, -4L, and -5L, interacts with CDC45L and MCM10 (important for replication initiation), and has a role in transcriptional silencing. (NCI) ( NCI )] (UMLS (NCI) C1335135) ORC2L;
Origin of Replication 2 Homolog-Like;
Origin Recognition Complex Protein 2 Homolog;
Origin Recognition Complex Subunit 2;
Origin Recognition Complex Subunit 2-Like;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 14. orchidopexy
- [ ] (UMLS (CSP) C0194907) =Therapeutic or Preventive Procedure
|
- 5. ORC2L
- [This gene is involved in DNA binding and the initiation of DNA replication. It also plays a role in negative control of transcription. ( NCI )] (UMLS (NCI) C1335084) ORC2L Gene;
Origin Recognition Complex, Subunit 2-Like (Yeast) Gene;
=Gene or Genome ;
| - 15. orchitis
- [inflammation of one or both testis. ( CSP )] (UMLS (CSP) C0029191) =Pathologic Function ;
=Testicular Disease;
|
- 6. ORC3L
- [This gene plays a role in DNA binding and the initiation of DNA replication. It is also involved in transcriptional silencing. ( NCI )] (UMLS (NCI) C1335085) ORC3L Gene;
Origin Recognition Complex, Subunit 3-Like (Yeast) Gene;
=Gene or Genome | - 16. Orchitis and epididymitis in diseases classified elsewhere
- [ ] (UMLS (ICD9CM) C0156303) =Disease or Syndrome ;
|
- 7. ORC4
- [Human ORC4L Gene (ORC4 Family) encodes 436-aa 50-kDa nuclear Origin Recognition Complex Subunit 4, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. ORC4L has a putative nucleotide triphosphate binding motif, associates with multiple cellular proteins, forms a core ORC complex with ORC2L, -3L, and -5L, and has a role in transcriptional silencing. (NCI) ( NCI )] (UMLS (NCI) C1335136) ORC4L;
ORC4P;
Origin Recognition Complex Subunit 4;
Origin Recognition Complex Subunit 4-Like =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 17. ORCHITIS WITH ABSCESS
- [ ] (UMLS (ICD9CM) C0156301) =Acquired Abnormality; Disease or Syndrome
|
- 8. ORC4L
- [This gene is involved in DNA binding, initiation of DNA replication and transcriptional silencing. It also plays a role in ATP hydrolysis and the maintenance of cell viability. ( NCI )] (UMLS (NCI) C1335086) ORC4L Gene;
Origin Recognition Complex, Subunit 4-Like (Yeast) Gene;
=Gene or Genome | - 18. ORCHITIS/EPIDIDYMIT NEC
- [ ] (UMLS (ICD9CM) C0156302) =Disease or Syndrome ;
|
- 9. ORC5
- [Abundantly expressed in spleen, ovary, testes, colon mucosa, and prostate, human ORC5L Gene (ORC5 Family) encodes 435-aa 50-kDa nuclear Origin Recognition Complex Subunit 5, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. While ORC5 forms a core ORC complex with ORC2L, -3L, and -4L, the ORC5T isoform interacts with ORC4L, but not ORC2L, and regulates assembly of different ORC subcomplexes. ORC5 has a role in transcriptional silencing. (NCI) ( NCI )] (UMLS (NCI) C1335137) ORC5L;
ORC5P;
ORC5T;
Origin Recognition Complex Subunit 5;
Origin Recognition Complex Subunit 5-Like;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 19. Orchitis/epididymitis
- (UMLS (ICPC) C0149881) (Orchitis/epididymitis; ORKITISA/EPIDIDIMITISA; Orkit/epididymit; Orchitis/epididymitis; KIVESTULEHDUS/LISAKIVESTULEHDUS; Orchite/epidydimite; Orchitis/Epididymitis; (108); orchitis/epididymitis; Orchite/epididimite; ORKITT/EPIDIMYDITT/TESTIK.BETENN; Orquite/epididimite; Orquitis/epididimitis; ORKIT/EPIDIDYMIT) =Disease or Syndrome =Diagnosis/Diseases Component; Body System, Reproductive, Male
|
- 10. ORC5L
- [This gene plays a role in DNA binding and the initiation of DNA replication. It is also involved in negative regulation of transcription. ( NCI )] (UMLS (NCI) C1335087) ORC5L Gene;
Origin Recognition Complex, Subunit 5-Like (Yeast) Gene;
=Gene or Genome | |
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