- 1. 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
- [antimetabolite used in the treatment of pancreatic, lung, and other cancers. ( CSP )] (UMLS (NCI) C0045093) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=antimetabolite;
[AN000] ANTINEOPLASTICS;
deoxycytidine;
=1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride | - 8. 8-Oxoguanine DNA Glycosylase
- [The protein 8-Oxoguanine DNA Glycosylase, encoded by the OGG1 gene, is an enzyme in base excision repair. OGG1 incises DNA at 8-oxoguanine residues and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 also has activities of beta-lyase that nicks DNA 3-prime to the lesion and endonuclease that cleaves DNA near apurinic or apyrimidinic sites to products with 5-prime-phosphate. Alternative splicing of the C-terminal region of the OGG1 gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common (1a/alpha, 1b, 1c, 2a/beta, 2b, 2c, 2d and 2e) and 1a is the prevalent form. OGG1 is ubiquitous and located in nucleus (isoform 1a) and mitochondria (isoform 2a). Defects in OGG1 are associated with tumor formation. ( NCI )] (UMLS (NCI) C1363852) N-Glycosylase/DNA Lyase;
OGG1 =Amino Acid, Peptide, or Protein; Enzyme |
- 2. 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride
- [The hydrochloride salt of an antimetabolite analog of the nucleoside pyrimidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. ( NCI )] (UMLS (NCI) C0771488) 2'Deoxy-2',2'-Difluorocytidine, Hydrochloride;
Difluorodeoxycytidine Hydrochloride;
Gemcitabine Hydrochloride;
GEMCITABINE HYDROCHLORIDE PREPARATION =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose;
=GEMCITABINE HYDROCHLORIDE 1 GM;
GEMCITABINE HYDROCHLORIDE 200 MG | - 9. 8-Oxoguanine DNA Glycosylase Gene
- [This gene is involved in base excision repair of oxidatively damaged DNA. ( NCI )] (UMLS (NCI) C1335081) OGG1;
OGG1 Gene;
=Gene or Genome ;
|
- 3. 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
- [2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine; cyclophosphamide analog with two alkylating groups, used as a DNA strand crosslinker and antineoplastic. ( CSP )] (UMLS (NCI) C0020823) =Organophosphorus Compound; Pharmacologic Substance ;
=Alkylating Activity;
[AN000] ANTINEOPLASTICS;
(-)-Cyclophosphamide;
phosphamide;
oxazine;
Antineoplastic Alkylating Agent =IFOSFAMIDE 1 GM/VIL;
IFOSFAMIDE 3 GM;
IFOSFAMIDE 1 GM;
| - 10. OXO
- [The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Oxonate (Oxo), one of the components of the antineoplastic agent S1, inhibits the enzyme orotate phosphoribosyltransferase which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxo is selectively distributed to the intracellular sites of tissues lining the small intestines, thereby, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased with S1 therapy. ( NCI )] (UMLS (NCI) C0393003) =Organic Chemical; Pharmacologic Substance ;
|
- 4. 22-Oxovincaleukoblastine
- [inhibits microtubule formation in the mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. ( CSP )] (UMLS (NCI) C0042679) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
vinca alkaloid =Leurocristine Sulfate | - 11. oxoacid lyase
- [ ] (UMLS (CSP) C0597154) =Amino Acid, Peptide, or Protein; Enzyme =carbon carbon lyase;
=citrate (si) synthase;
|
- 5. 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2
- [catalyzes the reduction of testosterone to 5 alphadihydrotestosterone. ( CSP )] (UMLS (NCI) C0039602) =Amino Acid, Peptide, or Protein; Enzyme ;
=hydrocarbon oxidoreductase;
| - 12. oxoglutarate decarboxylase
- [ ] (UMLS (CSP) C0311624) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 6. 3-oxobutyrate
- [ ] (UMLS (CSP) C1536988) =Organic Chemical
| - 13. Oxolamine
- (UMLS (NCI) C0069787) =Organic Chemical; Pharmacologic Substance ;
|
- 7. 8-Oxo-2'-Deoxyguanosine
- [A type of altered DNA base caused by oxidative DNA damage. ( NCI )] (UMLS (NCI) C0081381) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance
| - 14. oxotremorine
- [A non-hydrolyzed muscarinic agonist used as a research tool. ( MSH )] (UMLS (CSP) C0030038) =Organic Chemical; Pharmacologic Substance
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