- 1. PLZF
- [Expressed in early myeloid cells, peripheral mononuclear cells, and in ovary, kidney, and lung by retinoic acid induced human ZNF145 Gene (Krueppel Family), alternative isoforms PLZFA (550-aa) and PLZFB (673-aa, 74-kDa) of nuclear Zinc Finger Protein 145 are probable transcription factors containing a BTB/POZ domain. Conserved N-terminal protein interaction BTB/POZ domains of some C2H2 transcription factors interact with components of histone deacetylase complex and repress transcription. ZNF145 may play a role in myeloid maturation and development, or maintenance of differentiated tissues. A growth-inhibitory and pro-apoptotic factor in limb bud formation, ZNF145 is an axial and appendicular skeletal anterior/posterior patterning mediator that regulates HOX gene expression. APL associated translocation t(11;17)(q32;q21) involves ZNF145 and RARA. (NCI) ( NCI )] (UMLS (NCI) C0294292) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2. PLZF-RARA Chimera
- [Translocation t(11;17)(q23;21) fuses the PLZF gene on 11q23.1 to the RARA gene on chromosome 17 producing a 'dominant-negative' PLZF-RARA fusion protein in myeloid cells and resulting in APL. The oncogenic retinoic acid receptor mediates leukemogenesis through aberrant chromatin acetylation. Through the RAR-alpha CoR box, PLZF-RAR-alpha fusion proteins recruit the NCOR/histone deacetylase complex. (from OMIM 176797 and NCI) ( NCI )] (UMLS (NCI) C0765587) PLZF-RARalpha;
Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha Chimera;
ZNF145/RARA Chimera =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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