- 1. (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1)
- [The tromethamine salt form of fosfomycin, a synthetic broad-spectrum antibiotic. Fosfomycin tromethamine binds to and inactivates the enzyme enolpyruvyl transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis. In addition, fosfomycin tromethamine reduces the adherence of bacteria to uroepithelial cells. (NCI05) ( NCI )] (UMLS (NCI) C0543454) =Organophosphorus Compound; Antibiotic ;
=FOSFOMYCIN;
1,3-Propanediol, 2-Amino-2-(hydroxymethyl)- =FOSFOMYCIN TROMETHAMINE 3 GM | - 16. RS 25259-197
- (UMLS (NCI) C0288369) =Organic Chemical; Pharmacologic Substance
|
- 2. (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,2
- [A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05) ( NCI )] (UMLS (NCI) C0541315) =Organic Chemical; Pharmacologic Substance
| - 17. RS-21592
- (UMLS (NCI) C0701306) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 3. (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b
- (UMLS (NCI) C0056789) =Organic Chemical ;
| - 18. RS-35887
- (UMLS (NCI) C0733449) =Organic Chemical; Pharmacologic Substance
|
- 4. (2R,3S)-N-Hydroxy-N-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
- [An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Batimastat is a matrix metalloproteinase inhibitor. ( NCI )] (UMLS (NCI) C0215791) =Organic Chemical; Pharmacologic Substance ;
| - 19. RS-94991298
- (UMLS (NCI) C0733433) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|
- 5. (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentad
- [semi-synthetic macrolide antibiotic; related to erythromycin. ( CSP )] (UMLS (NCI) C0052796) =Organic Chemical; Antibiotic =macrolide antibiotic;
ERYTHROMYCIN;
[AM200] ERYTHROMYCINS/MACROLIDES;
=AZITHROMYCIN DIHYDRATE;
AZITHROMYCIN 100 MG/5ML;
AZITHROMYCIN 250 MG;
AZITHROMYCIN 200 MG/5ML;
AZITHROMYCIN 600 MG;
AZITHROMYCIN 500 MG;
| - 20. Rsc8
- [A subunit of unknown function in the fifteen-protein RSC nucleosome/chromatin remodeling complex, Rsc8/Swh3 is a homolog of the SWI/SNF protein SWI3. Swi3/BAF155 contains a leucine zipper motif typical of many transcription factors. Swh3p undergoes dimerization via the coiled-coil C-terminus, forms a complex with RSC6p, interacts with the SWI2/SNF2 ATPase Sth1p, and appears to mediate multiple RSC interactions. SWI/SNF and RSC share conserved components. SWI/SNF proteins display helicase and ATPase activities and appear to regulate gene transcription by altering local chromatin structure. RSC complex is required for transcriptional regulation and nucleosome positioning. RSC maintains a repressive chromatin structure at certain inducible promoters. (from SGD; NAR 26:3739, 1998; EMBO J. 18:2836, 1999; and NCI) ( NCI )] (UMLS (NCI) C1455624) Rsc8/Swh3;
Swh3;
Swh3p;
YFR037C =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6. (2R,3S,4S,5E,7S,8S,9R)-2,9- Dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene
- [Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts transformed with v-ras and v-src oncogenes to the flattened phenotype of the non-transformed parental cells. The mechanism of de-transformation induced by this agent had not been determined. However, depudecin has been demonstrated to inhibit histone deacetylase (HDAC) activity effectively both in vivo and in vitro. ( NCI )] (UMLS (NCI) C0113086) =Organic Chemical; Biologically Active Substance ;
| - 21. RSH Syndrome
- [autosomal recessive disorder characterized by multiple congenital anomalies including microcephaly, mental retardation, unusual facies, and genital abnormalities; the biochemical defect is a lack of 7-dehydrocholesterol-delta-7-reductase, resulting in abnormally high levels of 7-dehydrocholesterol and low levels of cholesterol. ( CSP )] (UMLS (CSP) C0175694) =Congenital Abnormality; Disease or Syndrome =Abnormalities, Multiple;
Lipid Metabolism, Inborn Errors;
syndrome;
inborn lipid/lipoprotein disorder;
congenital disorder;
|
- 7. (3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) Carbamate
- (UMLS (NCI) C0081489) =Organic Chemical; Pharmacologic Substance
| - 22. RSP - Personnel Information by Segment Response
- (UMLS (HL7) C1549219) =Health Care Activity =Event Type;
|
- 8. (3R,5S,6E)-(+/-)-7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic Acid
- [The sodium salt of a synthetic lipid-lowering agent with potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. ( NCI )] (UMLS (NCI) C0246203) =Organic Chemical; Pharmacologic Substance ;
=FLUVASTATIN;
=FLUVASTATIN SODIUM 20 MG;
FLUVASTATIN SODIUM 40 MG;
FLUVASTATIN SODIUM 80 MG | - 23. RSP - Segment pattern response in response to QBP^Q11
- (UMLS (HL7) C1549212) =Health Care Activity =Event Type;
|
- 9. (6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Monohydrate
- [A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents. ( NCI )] (UMLS (NCI) C0065295) =Organic Chemical; Antibiotic ;
=[AM130] BETA-LACTAMS ANTIMICROBIALS, OTHER;
Unclassified Ingredients =LORACARBEF 100 MG/5ML;
LORACARBEF 200 MG;
LORACARBEF 200 MG/5ML;
LORACARBEF 400 MG | - 24. RSP _ Allocate identifiers response
- (UMLS (HL7) C1549218) =Health Care Activity =Event Type;
|
- 10. (R,S)-N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino] propyl]tetrahydro-2-furancarboxamide Hydrochloride
- [The hydrochloride salt of alfuzosin, a quinazoline compound with smooth muscle-relaxing activity. Alfuzosin selectively binds to and antagonizes post-synaptic alpha-1-adrenoreceptors in smooth muscle of the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra, initiating relaxation of smooth muscle and resulting in improvement of urine flow and the symptoms of benign prostatic hyperplasia (BPH). This agent also blocks alpha-1-adrenoreceptors in peripheral vascular smooth muscle, resulting in vasodilatation and a decrease in peripheral vascular resistance. ( NCI )] (UMLS (NCI) C0102130) =Organic Chemical; Pharmacologic Substance ;
| - 25. RSP _ Find candidates response
- (UMLS (HL7) C1549216) =Health Care Activity =Event Type;
|
- 11. (RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ butyraldehyde
- [A steroid being studied as an anticancer drug. Budesonide is commonly used to treat asthma and rhinitis. ( NCI )] (UMLS (NCI) C0054201) =Steroid; Pharmacologic Substance =Pregnenediones;
[NT200] ANTI-INFLAMMATORIES, NASAL;
[RE101] ANTI-INFLAMMATORIES, INHALATION;
=Budesonide 0.2 MG/ACTUAT;
BUDESONIDE 3 MG;
BUDESONIDE 0.25 MG/ML;
Budesonide 0.32 MG/ACTUAT;
| - 26. RSP _ Get corresponding identifiers response
- (UMLS (HL7) C1549217) =Health Care Activity =Event Type;
|
- 12. 5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-one
- [A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors. ( NCI )] (UMLS (NCI) C1176306) APREPITANT;
APREPITANT UNIDENTIFIED;
APREPITANT PREPARATION;
APREPITANT UNIDENTIFIED =Organic Chemical; Pharmacologic Substance =[GA700] ANTIEMETICS;
Unclassified Ingredients =APREPITANT 125 MG;
APREPITANT 80 MG;
APREPITANT 125MG X1/80MG X2 CAP,PKT,3 | - 27. RSP _ Get person demographics response
- (UMLS (HL7) C1549215) =Health Care Activity =Event Type;
|
- 13. Rs
- [Supernumerary mandibular right primary canine ( HL7V3.0 )] (UMLS (HL7) C1552160) =Body Part, Organ, or Organ Component =SUPERNUMERARY TEETH;
| - 28. RSR 13
- [A drug that may increase the effectiveness of radiation therapy. ( NCI )] (UMLS (NCI) C0165792) =Organic Chemical; Pharmacologic Substance
|
- 14. RS
- [A country in Northern Asia (that part west of the Urals is sometimes included with Europe), bordering the Arctic Ocean, between Europe and the North Pacific Ocean. (NCI) ( NCI )] (UMLS (NCI) C0035970) =Geographic Area
| - 29. RSV-MAb
- [respiratory syncytial virus monoclonal antibody (palivizumab), intramuscular ( HL7V3.0 )] (UMLS (HL7) C1548495) =Pharmacologic Substance; Immunologic Factor ;
=Vaccines administered (code = CVX)(parenteral, unless oral is noted);
VaccineType |
- 15. RS 10029
- (UMLS (NCI) C0073623) =Organic Chemical; Pharmacologic Substance
| |
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